| 李欣,吕芸,张玥钰,等.细菌裂解物治疗慢性鼻窦炎的研究进展[J].安徽医药,2025,29(2):213-218. |
| 细菌裂解物治疗慢性鼻窦炎的研究进展 |
| Progress in the treatment of chronic sinusitis with bacterial lysate |
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| DOI：10.3969/j.issn.1009-6469.2025.02.001. |
| 中文关键词: 免疫因子类 鼻窦炎 免疫调节剂 细菌裂解物 免疫疗法 |
| 英文关键词: Immunologic factors Sinusitis Immune modulator Bacterial lysate Immunotherapy |
| 基金项目:甘肃省人民医院国家级科研项目培育计划一般项目( 19SYPYB-14)；甘肃省人民医院科技计划项目( 20JR10RA391) |
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| 摘要点击次数: 1253 |
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| 中文摘要: |
| 慢性鼻窦炎(CRS)是一种常见的耳鼻喉科疾病，由于 CRS的高患病率及高复发率，给个人、家庭和整个社会带来了巨大的健康和经济负担。目前， CRS的患病率仍呈上升趋势。尽管在过去几十年里，在治疗和控制 CRS方面取得了重大进展，但仍存在一定的局限性。因此寻找其他预防策略就变得尤其重要。近年来有学者提出非特异性免疫调节化合物可改变免疫系统对感染性疾病的反应，笔者收集了非特异性免疫调节剂治疗 CRS的有效性相关数据，数据揭示了免疫调节剂对 CRS的作用主要是通过肠 -肺免疫轴、增加鼻窦上皮细胞一氧化氮反应以及纤毛摆动频率实现的。此类药物可能为减轻鼻部症状、预防 CRS的感染和复发提供了另一种新的方法。目前最具代表性的非特异性免疫调节剂为细菌裂解物，现总结细菌裂解物在 CRS中的作用机制及相关临床研究进展，旨在为细菌裂解物在 CRS中的应用提供一定的理论指导。 |
| 英文摘要: |
| Chronic sinusitis (CRS) is a common otorhinolaryngological disease.Due to the high prevalence and recurrence rate of CRS,it brings huge health and economic burden to individuals, families and the whole society. At present, the prevalence of CRS is still onthe rise. Although great progress has been made in the treatment and control of CRS in the past few decades, there are still some limita-tions. Therefore, it is particularly important to find other prevention strategies. In recent years, some scholars have proposed that non-specific immunomodulators can change the response of the immune system to infectious diseases. We have collected data on the effec-tiveness of nonspecific immunomodulators in the treatment of CRS. The data reveal that the effect of oral immunomodulators on CRS ismainly achieved through the intestinal-pulmonary immune axis and increasing the NO response of paranasal sinus epithelial cells andthe frequency of cilia wobble. These drugs may provide another new method for relieving nasal symptoms and preventing CRS infectionand recurrence. At present, the most widely used non-specific immunomodulator is bacterial lysate. This paper summarizes the actionmechanism of bacterial lysate in CRS and related clinical research progress, in order to provide some theoretical guidance for the appli-cation of bacterial lysate in CRS. |
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