| 王利,王超,邱晓晖,等.CT血流储备分数、斑块参数及管腔内密度衰减梯度在评估冠状动脉功能性狭窄中的价值[J].安徽医药,2025,29(2):289-293. |
| CT血流储备分数、斑块参数及管腔内密度衰减梯度在评估冠状动脉功能性狭窄中的价值 |
| The value of CT fractional flow reserve, plaque parameters, transluminal attenuation gradient in vascular functional stenosis |
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| DOI：10.3969/j.issn.1009-6469.2025.02.015 |
| 中文关键词: 冠状动脉狭窄 血流储备分数 斑块 管腔内密度衰减梯度 冠状血管造影术 |
| 英文关键词: Coronary stenosis Fractional flow reserve Plaque Transluminal attenuation gradient Coronary angiography |
| 基金项目:亳州市人民医院科研项目库项目(by2023032) |
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| 中文摘要: |
| 目的探讨 CT血流储备分数( CT-FFR)、斑块参数及管腔内密度衰减梯度( TAG)在评估冠状动脉功能性狭窄中的价值。方法收集亳州市人民医院 2022年 1月至 2023年 9月行冠状动脉 CT血管造影(CCTA)检查并发现冠状动脉斑块病人 186例，共 215支病变血管，测量、评估病变血管斑块性质、斑块长度、斑块总体积、血管狭窄程度、 TAG以及 CT-FFR值，并进行统计学分析。结果 215支病变血管分为功能性狭窄组(CT-FFR≤0.80)114例和无功能性狭窄组(CT-FFR>0.80)101例，功能性狭窄组斑块长度( 28.05 mm比 9.30 mm)、斑块总体积( 70.41 mm3比 12.51 mm3)均高于无功能性狭窄组，差异有统计学意义(均 P< |
| 英文摘要: |
| Objective To investigate the relationship between vascular functional stenosisandplaque parameters,transluminal attenu-ation gradient (TAG),CT fractional flow reserve (CT-FFR).Methods A total of 186 patients with coronary artery plaque detected bycoronary CTA in Bozhou People's Hospital from January 2022 to September 2023 were collected, with a total of 215 diseased vessels.The plaque properties, plaque length, total plaque volume, degree of vascular stenosis, TAG and CT-FFR values of the diseased vessels were measured and evaluated, and statistical analysis was performed.Results A total of 215 diseased vessels were divided into func-tional stenosis group (CT-FFR≤0.80)114 cases and non-functional stenosis group (CT-FFR>0.80) 101 cases. The plaque length(28.05 mm vs.9.30 mm) and total plaque volume(70.41 mm3 vs.12.51 mm3) in the functional stenosis group were higher than those in the non-functional stenosis group, and the differences were statistically significant (P<0.001). The incidence of mixed plaque in the functional stenosis group was higher than that in the non-functional stenosis group, and the incidence of calcified plaque was the opposite, the dif-ference was statistically significant (P<0.001). There were significant differences in the incidence of mild, moderate and severe stenosis between the two groups (all P<0.001). There was a linear negative correlation between CT-FFR and plaque length and total plaque vol-ume (all P<0.001). There was no linear relationship between CT-FFR and TAG. The areas under curve (AUC) values of vascular func-tional stenosis diagnosed by the degree of vascular stenosis, plaque length, total plaque volume, plaque properties and plaque length &total plaque volume & the degree of vascular stenosis combined index were 0.87, 0.80, 0.81, 0.58 and 0.89, respectively (P<0.001,P< 0.001,P<0.001,P=0.042,P<0.001).Conclusions The increase in the severity of vascular stenosis and mixed plaques(compared with non-calcified plaques and calcified plaques) are more likely to lead to vascular functional stenosis. Plaque length and total plaque vol-ume were negatively correlated with CT-FFR, there is no significant correlation between TAG and CT-FFR. In addition, plaque length& total plaque volume & the degree of vascular stenosis combined index was superior to single index in the diagnosis of vascular func-tional stenosis. |
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