| 刘龙生,万玉峰,丁绍慧,等.分泌性中耳炎耳鸣症状发生情况及与炎症反应的关联性[J].安徽医药,2025,29(2):298-301. |
| 分泌性中耳炎耳鸣症状发生情况及与炎症反应的关联性 |
| Occurrence of tinnitus and its correlation with inflammation response in patients with secretory otitis media |
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| DOI：10.3969/j.issn.1009-6469.2025.02.017 |
| 中文关键词: 伴渗出液中耳炎 耳鸣 白细胞介素 -6 白细胞介素 -8 肿瘤坏死因子 -α |
| 英文关键词: Otitis media with effusion Tinnitus Interleukin-6 |
| 基金项目:安徽省高校自然科学研究项目( KJ2019A0260) |
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| 中文摘要: |
| 目的探讨分泌性中耳炎( OME)耳鸣症状发生情况及与炎症反应的关联性。方法选取 2021年 1月至 2022年 8月安徽医科大学附属巢湖医院收治的 104例 OME病人为研究对象，另取同期 104例体检健康者为对照组，比较两组炎症反应指标及耳鸣发生情况，并根据耳鸣发生情况将 OME病人分为耳鸣组( n=19)和无耳鸣组( n=85)比较两组 OME病人炎症反应指标，分析炎症反应指标对 OME病人耳鸣的诊断价值。结果 OME组白细胞介素( IL)-6、IL-8及肿，瘤坏死因子 -α(TNF-α)水平高于对照组( P<0.05)； OME组耳鸣发生率为 18.27%，高于对照组的 4.81%(P<0.05)；耳鸣组 IL-6、IL-8及 TNF-α水平高于无耳鸣组(P<0.05)； ROC曲线显示， IL-6诊断 OME病人耳鸣的 AUC和截断值分别为 0.77、4.04 ng/L，IL-8诊断 OME病人耳鸣的 AUC和截断值分别为 0.81、12.41 ng/L，TNF-α诊断 OME病人耳鸣的 AUC和截断值分别为 0.69、3.96 ng/L，三者联合诊断 OME病人耳鸣的 AUC为 0.89，高于单项预测( P<0.05)。结论 OME病人耳鸣发生情况较为严重， IL-6、IL-8及 TNF-α均可以用来诊断 OME病人耳鸣症状，且联合诊断价值更高。 |
| 英文摘要: |
| Objective To explore the occurrence of tinnitus and its correlation with inflammation response in patients with otitis me-dia with effusion (OME).Methods A total of 104 patients with OME admitted to the Chaohu Hospital of Anhui Medical Universitywere enrolled as the research objects between January 2021 and August 2022, while 104 healthy controls during the same period wereenrolled as control group. The inflammatory response indexes and occurrence of tinnitus in the two groups were compared. According topresence or absence of tinnitus, OME patients were divided into tinnitus group (n=19) and non-tinnitus group (n=85), and inflammatoryresponse indexes in the two groups were compared. The diagnostic value of inflammatory response indexes for tinnitus was analyzed.Re. sults The levels of IL-6, IL-8 and TNF-α in OME group were higher than those in control group (P<0.05). The incidence of tinnitus in OME group was higher than that in control group (18.27% vs. 4.81%, P<0.05). The levels of IL-6, IL-8 and TNF-α in tinnitus group were higher than those in non-tinnitus group (P<0.05). ROC curves analysis showed that AUC and cut-off values of IL-6, IL-8 and TNF-α in the diagnosis of tinnitus were (0.77, 4.04 ng/L), (0.81, 12.41 ng/L) and (0.69, 3.96 ng/L), respectively. AUC of combined detectionwas 0.89, which was greater than that of single index (P<0.05).Conclusion Tinnitus is severe in OME patients. IL-6,IL-8 and TNF-α can be applied to diagnose tinnitus, and diagnostic value of combined detection is higher. |
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