| 吴宗汶,廖亚周,黄乘胜,等.乳腺癌与甲状腺癌的发病相关性分析[J].安徽医药,2025,29(2):306-309. |
| 乳腺癌与甲状腺癌的发病相关性分析 |
| Correlation analysis of patients with breast cancer and thyroid cancer |
| |
| DOI：10.3969/j.issn.1009-6469.2025.02.019 |
| 中文关键词: 肿瘤，多原发性 乳腺肿瘤 甲状腺肿瘤 雌激素受体 孕激素受体 三碘甲状腺原氨酸 甲状腺素 相关性分析 |
| 英文关键词: Neoplasms, multiple primary Breast neoplasms Thyroid neoplasms Estrogen receptor Progesterone receptor Triiodothyronine Thyroxine Correlation analysis |
| 基金项目: |
|
| 摘要点击次数: 627 |
| 全文下载次数: 331 |
| 中文摘要: |
| 目的分析原发性乳腺癌与甲状腺癌的临床病理特征，探讨两种原发性肿瘤发病的相关性。方法回顾性分析中山市人民医院于 2008年 1月至 2023年 7月收治的同时患有乳腺癌和甲状腺癌的女性病人 92例(双原发癌组)。另分别收集近两年该院收治的单发乳腺癌 100例(乳腺癌组)及单发甲状腺癌 100例(甲状腺癌组)，分析双原发癌组的一般特征、肿瘤先发顺序；比较双原发癌组与乳腺癌组一般特征、病理特征、淋巴结转移情况、雌激素受体(ER)、孕激素受体( PR)、人类表皮生长因子受体 2(HER-2)表达情况及分子分型，比较双原发癌组与甲状腺癌组的一般特征、病理特征、淋巴结转移情况、甲状腺激素及抗原抗体水平。结果双原发癌组中，其中乳腺癌先发 86例，甲状腺癌先发 6例，即绝大多数病人( >90%)乳腺癌先于甲状腺癌；与乳腺癌组相比，双原发癌组确诊时年龄更小，更多处于绝经前状态，肿瘤长径更大， ER、PR更多呈阳性表达，差异有统计学意义(均 P<0.05)。与甲状腺癌组相比，双原发癌组肿瘤发生在双侧的概率增加，且三碘甲状腺原氨酸( T3)及甲状腺素( T4)水平明显升高(均 P<0.05)。结论乳腺癌与甲状腺癌之间发病相关， ER阳性、 PR阳性、年龄小、绝经前状态及肿瘤长径偏大的乳腺癌病人应重视甲状腺的常规检查，而高水平 T3、T4的甲状腺癌病人也不应忽视乳腺的可能恶性变。 |
| 英文摘要: |
| Objective To analyze the clinical and pathologyical characteristics of primary breast cancer and thyroid cancer and ex-plore potential correlations between the two primary tumors.Methods A retrospective analysis was conducted on 92 female patientswith simultaneous breast cancer and thyroid cancer (bilateral primary cancer group) admitted to the People's Hospital of Zhongshanfrom January 2008 to July 2023. Additionally, 100 cases of single breast cancer (breast cancer group) and 100 cases of single thyroidcancer (thyroid cancer group) treated in the past two years were collected. The study analyzed the general characteristics of the bilateralprimary cancer group, the sequence of tumor onset, and compared the general characteristics, pathological features, lymph node metas-tasis,estrogen receptor (ER), progesterone receptor (PR), and HER-2 expression, as well as molecular subtypes between the bilateralprimary cancer group and the breast cancer group. It also compared the general characteristics, pathological features, lymph node me-tastasis, thyroid hormone, and antibody levels between the bilateral primary cancer group and the thyroid cancer group. Results In the bilateral primary cancer group, 86 cases had breast cancer diagnosed first, while 6 cases had thyroid cancer diagnosed first, indicat-ing that the majority of patients (>90%) developed breast cancer before thyroid cancer. Compared to the breast cancer group, the bilater-al primary cancer group had a younger age at diagnosis, more were premenopausal, had larger tumor sizes, and showed more positive ex-pression of ER and PR, with statistically significant differences (all P<0.05). Compared to the thyroid cancer group, the bilateral prima-ry cancer group had an increased likelihood of tumors occurring on both sides and significantly elevated levels of triiodothyronine (T3)and thyroxine (T4) levels (all P<0.05). Conclusions There is a correlation between breast cancer and thyroid cancer. Clinically, breast cancer patients who are ER-positive, PR-positive, younger, premenopausal, and have larger tumor sizes should pay attention toroutine thyroid examinations. Similarly, thyroid cancer patients with high levels of T3 and T4 should not overlook the possibility of ma-lignancy in the breast. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
