| 何雯,许自成,承胜男,等.血清半乳糖凝集素 13、缺氧诱导因子 1a水平与过敏性鼻炎病儿视觉模拟评分法评分的相关性[J].安徽医药,2025,29(2):310-314. |
| 血清半乳糖凝集素 13、缺氧诱导因子 1a水平与过敏性鼻炎病儿视觉模拟评分法评分的相关性 |
| Correlation between serum Gal-13,HIF-1α levels and VAS score in children with allergic rhinitis |
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| DOI：10.3969/j.issn.1009-6469.2025.02.020 |
| 中文关键词: 鼻炎，过敏性 症状视觉模拟评分 半乳糖凝集素 13 缺氧诱导因子 -1α |
| 英文关键词: Rhinitis,allergic Symptoms visual analogue scale Galectin-13 Hypoxia-inducible factor-1α |
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| 中文摘要: |
| 目的探究血清半乳糖凝集素 13(Gal-13)、缺氧诱导因子 1α(HIF-1α)水平与过敏性鼻炎视觉模拟评分法( VAS)评分的相关性。方法选取 2022年 1月至 2023年 7月在安徽省儿童医院治疗的过敏性鼻炎病儿 69例，根据 VAS评分分为轻度组(n= 37)及中重度组( n=32)并选取非过敏性鼻炎病儿 54例作为非过敏性鼻炎组，以同期体检的 49例健康志愿者为对照组，采用酶联免疫吸附法检测血清，Gal-13、HIF-1α水平，并收集病儿临床资料进行比较。采用 Pearson法分析过敏性鼻炎病儿血清 Gal-13、HIF-1α水平与 VAS评分的相关性，绘制受试者操作特征曲线( ROC曲线)检测血清 Gal-13、HIF-1α水平对过敏性鼻炎病情程度的诊断价值。结果与对照组相比，非过敏性鼻炎组及过敏性鼻炎组的血清 Gal-13［(39.52±4.96)ng/L、(49.62±6.29)ng/L比(31.55±4.31)ng/L］、HIF-1α水平［(0.45±0.08)μg/L、(1.06±0.15)μg/L比(0.25±0.06)μg/L］显著增加(P<0.05)与非过敏性鼻炎组相比，过敏性鼻炎组的血清 Gal-13、HIF-1α水平也显著增加( P<0.05)；中重度组血清 Gal-13、HIF-1α水平显，著大于轻度组(P<0.05)；两组病儿的年龄、性别差异无统计学意义( P>0.05)，两组病儿的病程、免疫球蛋白( Ig)E、白细胞介素( IL)-4、IL-9、干扰素 γ(IFN-γ)以及 VAS评分差异有统计学意义( P<0.05)；血清 Gal-13、HIF-1α水平与 VAS评分均呈正相关( r=0.70，P<0.05；r= |
| 英文摘要: |
| Objective To investigate the correlation between serum Gal-13, HIF-1α levels and VAS score in children with allergic rhinitis .Methods A total of 69 children with allergic rhinitis who were treated in Anhui Children's Hospital from January 2022 to Ju-ly 2023 were collected and grouped into mild group (n=37) and moderate to severe group (n=32) according to VAS score. Fifty-four pa-tients with non-allergic rhinitis were regarded as non-allergic rhinitis group, and 49 healthy volunteers who underwent physical exami-nation were regarded as control group, enzyme-linked immunosorbent assay (ELISA) was applied to detect serum Gal-13 and HIF-1α levels, clinical data of patients were collected and compared. Pearson's method was applied to analyze the correlation between serumGal-13, HIF-1α levels and VAS score in allergic rhinitis children, receiver operating characteristic (ROC) curve was plotted to detectthe diagnostic value of serum Gal-13 and HIF-1α levels for the severity of allergic rhinitis in children.Results Compared with the con-trol group, the serum levels of Gal-13 [(39.52±4.96)ng/L, (49.62±6.29)ng/L vs. (31.55±4.31)ng/L] and HIF-1α [(0.45±0.08)μg/L, (1.06± 0.15)μg/L vs. (0.25±0.06)μg/L] in the non-allergic rhinitis group and allergic rhinitis group were obviously increased (P<0.05), com-pared with the non-allergic rhinitis group, the levels of serum Gal-13 and HIF-1α in the allergic rhinitis group were also obviously in-creased (P<0.05); the serum levels of Gal-13 and HIF-1α in the moderate to severe group were obviously higher than those in the mild group (P<0.05); analysis of the general data of children with allergic rhinitis revealed that there was no significant difference betweenthe age, genders of the two groups (P>0.05), and duration of the disease, IgE, IL-4, IL-9, IFN-γ, and VAS scores of the two groups yield-ed significant differences (P<0.05); the levels of serum Gal-13 and HIF-1α were positively correlated with VAS score (r=0.70, P<0.05; r =0.68, P<0.05); ROC curve was plotted, and the results showed that the AUC of serum levels of Gal-13, HIF-1α, and the combination was 0.84, 0.84, and 0.938, the combined diagnosis was significantly better than that of Gal-13 (Z=2.06, P=0.049) and HIF-1α (Z=2.50, P=0.012) diagnosed separately.Conclusion The levels of serum Gal-13 and HIF-1α in allergic rhinitis childrenwere positively corre-lated with the VAS score, and serum Gal-13 and HIF-1α have some reference value for the clinical diagnosis and severity assessment of allergic rhinitis. |
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