| 刘丽鸽,闫秋月,艾婧怡,等.血清血管生成素样蛋白 4、过氧化物酶体增殖物激活受体 γ表达水平与急性缺血性脑卒中预后的关系[J].安徽医药,2025,29(2):324-328. |
| 血清血管生成素样蛋白 4、过氧化物酶体增殖物激活受体 γ表达水平与急性缺血性脑卒中预后的关系 |
| The relationship between the expression levels of serum Angptl4 and PPARγ and the prognosis of patients with acute ischemic stroke |
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| DOI：10.3969/j.issn.1009-6469.2025.02.023 |
| 中文关键词: 卒中 脑梗死 血管生成素样蛋白 4 过氧化物酶体增殖物激活受体 γ 预后 |
| 英文关键词: Stroke Brain infarction Angiopoietin-like protein 4 Peroxisome proliferator activated receptor γ Prognosis |
| 基金项目:沧州市科技计划自筹经费项目( 213106036) |
| 作者 | 单位 | | 刘丽鸽 | 沧州市中心医院,脑血管病四科,河北沧州 061000 | | 闫秋月 | 沧州市中心医院,脑血管病四科,河北沧州 061000 | | 艾婧怡 | 沧州市中心医院,帕金森、运动障碍科,河北沧州 061000 | | 焦如东 | 沧州市中心医院,急诊医学部,河北沧州 061000 | | 李猛 | 沧州市中心医院,脑血管病四科,河北沧州 061000 |
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| 中文摘要: |
| 目的探究血清血管生成素样蛋白 4(Angptl4)、过氧化物酶体增殖物激活受体 γ(PPARγ)表达水平与急性缺血性脑卒中预后的关系。方法选取 2020年 2月至 2022年 6月沧州市中心医院收治的急性缺血性脑卒中病人 100例作为观察组，依据美国国立卫生研究院卒中量表( NIHSS)评分评估病情严重程度，分为轻症组( n=33，NIHSS评分 <6分)、中症组( n=39，6分≤NIHSS评分 <14分)、重症组(n=28，NIHSS评分 ≥14分)；根据治疗 90 d后改良 Rankin量表(mRs)评分评估预后，分为预后良好组(n=68，0~2分)、预后不良组( n=32，≥3分)；另选取同期健康志愿者 100例作为对照组。酶联免疫吸附试验( ELISA)检测血清 Angptl4、PPARγ表达水平，并进行组间比较；多因素 logistic回归分析急性缺血性脑卒中病人预后的影响因素；受试者操作特征曲线( ROC曲线)分析血清 Angptl4、PPARγ对预后的评估价值。结果观察组血清 Angptl4［(14.16±3.28)μg/L比( 11.52±2.36) μg/L］、 PPARγ［(38.54±9.63)ng/L比( 26.68±7.48)ng/L］表达水平高于对照组( P<0.05)；重症组血清 Angptl4、PPARγ表达水平高于轻症组和中症组，且中症组高于轻症组( P<0.05)；预后不良组年龄、 Angptl4、PPARγ、高血压比例、糖尿病比例、入院时 NIHSS评分均明显高于预后良好组( P<0.05)；血清 Angptl4、PPARγ、NIHSS评分为急性缺血性脑卒中病人预后的影响因素( P<0.05)；血清 Angptl4、PPARγ二者联合评估急性缺血性脑卒中病人预后的曲线下面积( AUC)为 0.98。结论血清 Angptl4、PPARγ表达水平较高的急性缺血性脑卒中病人病情较严重，预后较差，血清 Angptl4、PPARγ为急性缺血性脑卒中病人预后影响因素，能较好地评估病人预后情况。 |
| 英文摘要: |
| Objective To explore the relationship between the expression levels of serum angiopoietin like protein 4 (Angptl4), per-oxisome proliferator activated receptor γ (PPARγ) and the prognosis of patients with acute ischemic stroke.Methods A total of 100 patients with acute ischemic stroke admitted to Cangzhou Central Hospital from February 2020 to June 2022 were collected as thestudy group, and according to the severity of the condition evaluated by the National Institutes of Health Stroke Scale (NIHSS), the pa-tients were assigned into mild group (n=33, NIHSS score<6 points), moderate group (n=39, 6 points ≤ NIHSS score<14 points), and se-vere group (n=28, NIHSS score ≥ 14 points). According to the prognostic condition evaluated by modified Rankin scale (mRs) 90 daysafter treatment, the patients were grouped into a good prognosis group (n=68, 0-2 points) and a poor prognosis group (n=32, ≥ 3 points); another 100 healthy volunteers from the same period were collected as the control group. Enzyme-linked immunosorbent assay (ELISA)was applied to detect the expression levels of Angptl4 and PPARγ in serum, which were compared between groups; multivariate logisticregression was applied to analyze the influencing factors for the prognosis of patients with acute ischemic stroke; receiver operatingcharacteristic (ROC) curve was applied to analyze the prognostic evaluation value of serum Angptl4 and PPARγ.Results The expres-sion levels of Angptl4 [(14.16±3.28) μg/L vs. (11.52±2.36) μg/L] and PPARγ [(38.54±9.63) ng/L vs. (26.68±7.48) ng/L] in the study group were higher than those in the control group (P<0.05). The expression levels of Angptl4 and PPARγ in the serum of the severegroup were higher than those of the mild and moderate groups, with the moderate group higher than the mild group (P<0.05). Age, Ang-ptl4, PPARγ, proportion of hypertension, proportion of diabetes, NIHSS score at admission in the poor prognosis group were obviouslyhigher than those in the good prognosis group (P<0.05). Serum Angptl4, PPARγ, and NIHSS scores were influencing factors for the prognosis of acute ischemic stroke patients (P<0.05). The area under the curve (AUC) of the combined evaluation of serum Angptl4 andPPARγ for the prognosis of acute ischemic stroke patients was 0.98.Conclusion Acute ischemic stroke patients with high expressionlevels of serum Angptl4 and PPARγ have more severe condition and worse prognosis. Serum Angptl4 and PPARγ are prognostic factorsfor patients with acute ischemic stroke, which can effectively evaluate the prognosis of patients. |
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