| 赵波,向超,杜雪梅,等.血清白细胞介素 -38、可溶性清道夫受体 163水平与支气管哮喘病儿肺功能、气道炎症的相关性[J].安徽医药,2025,29(2):349-353. |
| 血清白细胞介素 -38、可溶性清道夫受体 163水平与支气管哮喘病儿肺功能、气道炎症的相关性 |
| Correlation of serum IL-38, sCD163 levels with lung function and airway inflammation in children with bronchial asthma |
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| DOI：10.3969/j.issn.1009-6469.2025.02.028 |
| 中文关键词: 哮喘 白细胞介素 -38 可溶性清道夫受体 163 肺功能 气道炎症 |
| 英文关键词: Asthma Interleukin-38 Soluble scavenger receptor 163 Lung function Airway inflammation |
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| 中文摘要: |
| 目的探究支气管哮喘病儿血清白细胞介素 -38(IL-38)、可溶性清道夫受体 163(sCD163)水平与肺功能、气道炎症的相关性。方法选取 2020年 7月至 2022年 7月九〇三医院收治的 120例哮喘病儿作为研究对象，根据病情严重程度分为轻度组(n=48)、中度组( n=44)重度组(n=28)，收集病儿的基线资料，采用酶联免疫吸附法(ELISA)检测病儿血清 IL-38、sCD163、肿瘤坏死因子 -α(TNF-α)、白细、胞介素 -17(IL-17)水平，采用多重潮气呼吸法检测呼出气一氧化氮( FeNO)，并检测肺功能指标，包括第 1秒最大呼气量( FEV1)、最大呼气峰流速( PEF)、 FEV1/用力肺活量( FVC)，比较组间差异。 Pearson法分析血清 IL-38、 sCD163水平与肺功能指标、气道炎症指标的相关性； logistic回归分析血清 IL-38、sCD163与哮喘病儿病情严重程度的关系。结果轻度组、中度组、重度组病儿血清 IL-38水平［( 76.78±16.39)mg/L、(63.54±15.23)mg/L、(51.82±13.67)mg/L］逐渐降低， sCD163水平［( 62.37±15.42)ng/L、(73.15±17.21)ng/L、(82.97±18.64)ng/L］逐渐升高( P<0.05)；轻度组、中度组、重度组病儿 FEV1、PEF、FEV1/FVC逐渐降低，血清 TNF-α、IL-17水平及 FeNO逐渐升高( P<0.05)。 Pearson法分析结果显示血清 IL-38与 FEV1、PEF、FEV1/FVC呈正相关，与 TNF-α、IL-17、FeNO呈负相关；血清 sCD163与 FEV1PEF、FEV1/FVC呈负相关，与 TNF-α、IL-17、FeNO呈正相关( P<0.05)。 logistic回归分析结果显示，血清 IL-38、sCD163是哮喘病儿、病情严重程度的影响因素( P<0.05)。结论血清 IL-38、sCD163水平与哮喘病儿的肺功能及气道炎症均存在一定相关性，是病儿病情严重程度的影响因素，可为儿童哮喘的临床诊断及治疗提供新的思路。 |
| 英文摘要: |
| Objective To explore the correlation of the levels of serum interleukin-38 (IL-38), soluble scavenger receptor 163 (sCD163) with lung function and airway inflammation in children with bronchial asthma.Methods A total of 120 asthmatic children admitted to 903 Hospital from July 2020 to July 2022 were selected as the study subjects, according to the severity of the disease, andwere grouped into mild group (n=48), moderate group (n=44), and severe group (n=28). The baseline data of children were collected, the serum levels of IL-38, sCD163, tumor necrosis factor-α (TNF-α) and interleukin-17 (IL-17) were detected by enzyme-linked immuno-sorbent assay (ELISA), the exhaled nitric oxide (FeNO) was measured by multiple tidal breathing method, and the lung function index-es, including the maximum expiratory volume in the first second (FEV1), peak expiratory flow rate (PEF), and FEV1/forced vital capacity(FVC), were measured, then the differences between the groups were compared. Pearson method was applied to analyze the correlationbetween serum IL-38 and sCD163 levels and lung function indexes and airway inflammation indexes; and logistic regression was ap-plied to analyze the relationship between serum IL-38, sCD163 and the severity of asthma in children.Results The level of serum IL-38 [(76.78±16.39) mg/L, (63.54±15.23) mg/L, (51.82±13.67) mg/L] of children in mild, moderate and severe groups decreased gradual-ly, while the level of sCD163 [(62.37±15.42) ng/L, (73.15±17.21) ng/L, (82.97±18.64) ng/L] increased gradually (P<0.05). FEV1, PEF, FEV1/FVC of children in mild, moderate and severe groups decreased gradually, while the levels of serum TNF-α, IL-17 and FeNO in-creased gradually (P<0.05). Pearson's analysis results showed that serum IL-38 was positively correlated with FEV1, PEF, FEV1/FVC, but negatively correlated with TNF-α, IL-17, and FeNO; serum sCD163 was negatively correlated with FEV1, PEF, and FEV1/FVC, but positively correlated with TNF-α, IL-17, and FeNO (P<0.05). Logistic regression analysis results showed that serum IL-38 and sCD163 were the influential factors for the severity of asthma in children (P<0.05).Conclusion The levels of serum IL-38 and sCD163 have certain correlation with the lung function and airway inflammation of children with asthma, which are the influencing factors for the se-verity of children's disease, and can provide new ideas for the clinical diagnosis and treatment of children with asthma. |
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