| 富宏怡,杜海胜,李小玉,等.脐周八穴埋线对行体外受精 -胚胎移植术肥胖型多囊卵巢综合征不孕症妊娠结局、糖脂代谢及中医症候积分的影响[J].安徽医药,2025,29(2):388-392. |
| 脐周八穴埋线对行体外受精 -胚胎移植术肥胖型多囊卵巢综合征不孕症妊娠结局、糖脂代谢及中医症候积分的影响 |
| Effect of catgut embedding at eight acupoints around the umbilicus on pregnancy outcome, glucose and lipid metabolism and TCM syndrome score of obese patients with PCOS infertility undergoing IVF-ET |
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| DOI：10.3969/j.issn.1009-6469.2025.02.036 |
| 中文关键词: 多囊卵巢综合征 不育，女(雌)性 脐周八穴埋线 肥胖 中医症候积分 |
| 英文关键词: Polycystic ovary syndrome Infertility, female Catgut embedding at eight points around the umbilicus Obesity TCM syndrome score |
| 基金项目:河北省中医药管理局科研计划项目( 2021330) |
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| 中文摘要: |
| 目的探讨脐周八穴埋线对行体外受精 -胚胎移植术( IVF-ET)肥胖型多囊卵巢综合征( PCOS)不孕症病人妊娠结局、糖脂代谢及中医症候积分的影响。方法选取 2020年 10月至 2022年 3月河北省沧州中西医结合医院收治的 103例行 IVF-ET肥胖型 PCOS不孕症病人，按随机数字表法分为对照组( n=51，常规 IVF-ET治疗)和治疗组( n=52，常规 IVF-ET结合脐周八穴埋线治疗)。比较两组中医症候积分、心理状况［汉密尔顿焦虑量表( HAMA)、抑郁量表( HAMD)］、糖脂代谢指标［空腹血糖(FBG)、空腹胰岛素( FINS)、胰岛素抵抗指数( HOMA-IR)］、血脂指标［三酰甘油( TG)、高密度脂蛋白胆固醇( HDL-C)、低密度脂蛋白胆固醇( LDL-C)、总胆固醇( TC)］、身体质量指数( BMI)、腰臀比( WHR)、炎症因子［白细胞介素 -6(IL-6)、白细胞介素 -10(IL-10)、肿瘤坏死因子 -α(TNF-α)］及妊娠结局。结果治疗后，两组中医证候积分、 HAMA评分、 HAMD评分、 FBG、FINS、 HOMA-IR水平均较治疗前出现下降，治疗组治疗后上述指标水平分别为(6.02±1.68)分、(7.31±1.29)分、(6.86±1.39)分、(4.04± 0.64)mmol/L、(10.04±0.64)mIU/L、(1.61±0.04)分，低于对照组( 10.19±2.21)分、(10.42±2.36)分、(9.62±2.64)分、(5.32±1.02) mmol/L、(14.45±1.19)mIU/L、(2.11±0.06)分( P<0.05)。治疗组治疗后， IL-6、TNF-α、TG、LDL-C、TC、BIM、WHR水平为( 6.67± 1.38)ng/L、(22.18±2.23)ng/L、(1.21±0.05)mmol/L、(2.65±0.36)mmol/L、(3.12±0.45)mmol/L、(24.89±1.19)kg/m2、0.87±0.06，低于对照组( P<0.05)其 IL-10、HDL-C水平分别为( 167.46±31.25)ng/L、(2.01±0.19)mmol/L，高于对照组( 125.03±24.11)ng/L、(1.32±0.21)mmol/L(P<05)。治疗组与对照组的临床妊娠率比较差异无统计学意义( 53.84%比 41.17%)(χ2=1.66，P=0.198)；治疗组流产率为 3.57 %，低于对照组 23.81 %(χ2=4.57，P=0.032)。两组均无不良反应发生。结论脐周八穴埋线治疗有助于降低肥.0，胖型 PCOS不孕症病人中医症候积分，改善其心理负性情绪、炎症反应，调节糖脂代谢，降低流产率，且安全可靠。 |
| 英文摘要: |
| Objective To explore the effects of catgut embedding at eight acupoints around the navel on pregnancy outcomes, glucoseand lipid metabolism, and traditional Chinese medicine syndrome scores in obese polycystic ovary syndrome (PCOS) infertility patientsundergoing in vitro fertilization embryo transfer (IVF-ET).Methods Totally 103 cases of obese PCOS infertility patients, who under-went IVF-ET in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine from October 2020 to March 2022, wererandomly assigned into control group (n=51, conventional IVF-ET treatment) and treatment group (n=52, conventional IVF-ET treat-ment combined with catgut embedding at eight acupoints around the umbilicus) by random number table method. A comparison wasmade between the two groups of the TCM syndrome scores, psychological status [Hamilton anxiety rating scale (HAM-A), Hamilton rat-ing scale for depression (HAM-D)], glucose and lipid metabolism indicators [fasting blood glucose (FBG), fasting insulin (FINS), homeo-stasis model assessment insulin resistance (HOMA-IR)], blood lipid indices [triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), total cholesterol (TC)], body mass index (BMI), waist to hip ratio (WHR), inflam-matory factors [interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α (TNF-α)] and pregnancy outcomes.Results After treatment, the TCM syndrome scores, HAMA scores, HAMD scores, FBG, FINS and HOMA-IR levels of the two groups were decreasedcompared with those before treatment. After treatment, the levels of the above indexes in the treatment group were (6.02±1.68), (7.31±1.29), (6.86±1.39), (4.04±0.64) mmol/L, (10.04±0.64) mIU/L, and (1.61±0.04), respectively, which were lower than those in the controlgroup (10.19±2.21), (10.42±2.36), (9.62±2.64), (5.32±1.02) mmol/L, (14.45±1.19) mIU/L, and (2.11±0.06) (P<0.05). After treatment in the treatment group, the levels of IL-6, TNF-α, TG, LDL-C, TC, BIM, WHR were (6.67±1.38) ng/L, (22.18±2.23) ng/L, (1.21±0.05)mmol/L, (2.65±0.36) mmol/L, (3.12±0.45) mmol/L, (24.89±1.19) kg/m2, and (0.87±0.06), which were lower than those in the control group (P<0.05). The levels of IL-10 and HDL-C were (167.46±31.25) ng/L, and (2.01±0.19) mmol/L, respectively, which were higherthan those in the control group [(125.03±24.11) ng/L, (1.32±0.21) mmol/L] (P<0.05). There was no difference in the clinical pregnancy rate between the treatment group and the control group (53.84% vs. 41.17%) (χ2=1.66, P=0.198); the abortion rate of the treatment group was 3.57%, lower than that of the control group, which was 23.81% (χ2=4.57, P=0.032). No adverse reactions occurred in both groups. Conclusion The treatment of catgut embedding at eight acupoints around the umbilicus is helpful to reduce the TCM syn-drome score of obese patients with PCOS infertility, and it can improve patients' negative emotions and inflammatory reactions, regulateglucose and lipid metabolism, and reduce miscarriage rate, which is safe and reliable. |
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