| 倪飞珍.丹蒌通痹汤对冠心病心绞痛痰瘀阻络证临床疗效、心绞痛发作情况、脑钠肽及 6 min步行实验的影响[J].安徽医药,2025,29(2):395-399. |
| 丹蒌通痹汤对冠心病心绞痛痰瘀阻络证临床疗效、心绞痛发作情况、脑钠肽及 6 min步行实验的影响 |
| Effect of Danlou Tongbi decoction on clinical efficacy, angina attack, BNP and 6MWT in patients with angina pectoris of coronary heart disease with phlegm-stasis blocking collaterals syndrome |
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| DOI：10.3969/j.issn.1009-6469.2025.02.038 |
| 中文关键词: 冠心病 心绞痛 丹蒌通痹汤 痰瘀阻络证 脑钠肽 6 min步行实验 |
| 英文关键词: Coronary disease Angina pectoris Danlou Tongbi decoction Syndrome of phlegm-stasis blocking collaterals Brain natriuretic peptide 6 min walking experiment |
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| 中文摘要: |
| 目的探究丹蒌通痹汤对冠心病心绞痛痰瘀阻络证病人临床疗效、心绞痛发作情况、脑钠肽( BNP)及 6 min步行实验(6MWT)的影响。方法选取 2020年 6月至 2022年 6月永康市中医院收治的 94例冠心病心绞痛痰瘀阻络证病人。采用随机数字表法分为两组，对照组( 47例)进行常规的西药治疗，观察组( 47例)在对照组的基础上服用丹蒌通痹汤， 4周为 1个疗程，连续治疗 1个疗程。评估两组中医症状评分及临床疗效，统计心绞痛发作情况。检测两组治疗前后血清 BNP水平，比较两组 6MWT结果，并观察治疗方案的安全性。结果两组病人治疗后中医症状主症、次症及总评分均降低( P<0.05)，且观察组中医症状主症、次症及总评分均低于对照组( P<0.05)；观察组治疗总有效率为 91.47%，高于对照组的 74.47%(P<0.05)；两组病人心绞痛发作次数、持续时间、硝酸甘油用量及疼痛程度均降低( P<0.05)且观察组心绞痛发作次数、持续时间、硝酸甘油用量及疼痛程度均低于对照组( P<0.05)；两组治疗后 BNP水平降低、 6MWT水平，升高( P<0.05)且观察组 BNP水平低于对照组， 6MWT水平高于对照组( P<0.05)；对照组、观察组不良反应率分别为 12.77%、17.02%，差异无统，计学意义( P>0.05)。结论丹蒌通痹汤能够提高冠心病心绞痛痰瘀阻络证病人的临床疗效，改善临床症状和病人心功能，有效减少心绞痛的发作，安全性较高。 |
| 英文摘要: |
| Objective To explore the effects of Danlou Tongbi decoction on clinical efficacy, angina attack, brain natriuretic peptide(BNP) and 6 min walking test (6MWT) in patients with angina pectoris of coronary heart disease with phlegm-stasis blocking collaterals syndrome.Methods We selected 94 patients with angina pectoris of coronary heart disease with phlegm-stasis blocking collateralssyndrome, who were treated in Yongkang Traditional Chinese Medicine Hospital from June 2020 to June 2022, and assigned them intotwo groups by random number table method. The control group (n=47) received conventional western medicine treatment, while the ob-servation group (n=47) received additional Danlou Tongbi decoction for a continuous course of treatment with 4 weeks. The TCM symp-tom scores and clinical efficacy of the patients were evaluated, and the angina attacks of the patients were counted. Serum BNP levelswere detected before and after treatment, 6MWT results of the two groups were compared, and the safety of the treatment regimen wasobserved. Results The main symptom, secondary symptom and total scores of TCM symptoms in both groups were decreased after treatment (P<0.05), which were lower in the observation group than in the control group (P<0.05). The total effective rate of the observa-tion group was higher than that of the control group (91.47% vs. 74.47%; P<0.05). The frequency, duration, dosage of nitroglycerin and pain degree of angina pectoris were decreased in both groups (P<0.05) which were lower in observation group than in control group (P< 0.05). After treatment, the levels of BNP in two groups were decreased and the levels of 6MWT were increased (P<0.05), with the levelof BNP in the observation group lower than that in the control group, and the level of 6MWT higher than that in the control group (P< 0.05). The adverse reaction rates of control group and observation group were 12.77% and 17.02%, respectively, and there was no sig-nificant difference between them (P>0.05).Conclusion Danlou Tongbi decoction can improve the clinical efficacy of patients with an-gina pectoris of coronary heart disease with phlegm-stasis blocking collaterals syndrome, relieve clinical symptoms, enhance patients'heart function, and effectively reduce the attack of angina pectoris, which achieves high safety. |
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