| 陈凡平,宁红霞,汪海波,等.血府逐瘀汤联合法舒地尔对下肢动脉硬化闭塞症足背动脉血流量、间歇性跛行距离及 6-酮-前列腺素 F1α水平的影响[J].安徽医药,2025,29(2):409-412. |
| 血府逐瘀汤联合法舒地尔对下肢动脉硬化闭塞症足背动脉血流量、间歇性跛行距离及 6-酮-前列腺素 F1α水平的影响 |
| Influences of Xuefu Zhuyu decoction combined with fasudil on blood flow of dorsalis pedis artery, intermittent claudication distance and 6-keto-PGF1α level in patients with lower extremity arteriosclerosis obliterans |
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| DOI：10.3969/j.issn.1009-6469.2025.02.041 |
| 中文关键词: 闭塞性动脉硬化 血府逐瘀汤 法舒地尔 下肢 足背动脉血流量 间歇性跛行距离 6-酮-前列腺素 F1α |
| 英文关键词: Arteriosclerosis obliterans Xuefu Zhuyu decoction Fasudil Lower extremity Blood flow of dorsalis pedis artery Intermittent limping distance 6-keto-prostaglandin F1α |
| 基金项目:河北省中医药管理局资助项目( 2023377) |
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| 目的探究血府逐瘀汤联合法舒地尔对下肢动脉硬化闭塞症( ASO)病人足背动脉血流量、间歇性跛行距离及 6-酮-前列腺素 F1α(6-keto-PGF1α)水平的影响。方法纳入 2017年 1月至 2022年 6月石家庄市中医院接收的 90例下肢 ASO病人为研究对象，采用随机数字表法划分为对照组( 45例，法舒地尔治疗)与治疗组( 45例，法舒地尔 +血府逐瘀汤加减治疗)。对比两组临床疗效、足背动脉血流量、间歇性跛行距离及血清 6-keto-PGF1α水平。结果治疗组总有效率为 93.33%，高于对照组的 75.56%(P<0.05)。治疗后，两组间歇性跛行积分较治疗前下降，治疗组下降更明显( P<0.05)。治疗后，两组血清 6-keto-PGF1α水平、跛行距离均较治疗前增加，治疗组增加更明显( P<0.05)。治疗后，两组血管内径、血管峰值流速、血流量均显著改善，治疗组明显优于对照组(P<0.05)。结论血府逐瘀汤加减联合法舒地尔治疗下肢 ASO，安全性较好，可改善足背动脉血流量、间歇性跛行距离与 6-keto-PGF1α水平。 |
| 英文摘要: |
| Objective To investigate the influences of Xuefu Zhuyu decoction combined with fasudil on blood flow of dorsalis pedis artery, intermittent claudication distance and 6-keto-prostaglandin F1α (6-keto-PGF1α) level in patients with lower extremity arterioscle-rosis obliterans (ASO).Methods From January 2017 to June 2022, 90 patients with ASO of lower limbs were selected from Shijia-zhuang Traditional Chinese Medicine Hospital, the patients were randomly divided into control group (45 cases, treated with fasudil)and treatment group (45 cases, treated with fasudil combined with Xuefu Zhuyu decoction). The clinical efficacy, blood flow of dorsalis pedis artery, intermittent claudication distance and serum 6-keto-PGF1α level were compared between the two groups.Results The to-tal effective rate of the treatment group was 93.33%, which was higher than 75.56% of the control group (P<0.05). After treatment, thescore of intermittent claudication in the two groups decreased compared with that before treatment, and that in the treatment group de-creased more obviously (P<0.05). After treatment, the serum 6-keto-PGF1α level and limping distance in both groups were increasedcompared with those before treatment, and the increases in the treatment group were more obvious (P<0.05). After treatment, the diame-ter, peak velocity and blood flow of blood vessels in the two groups were obviously improved, and the treatment group were obviouslybetter than the control group (P<0.05). Conclusion The treatment of lower limb ASO patients with Xuefu Zhuyu decoction and re-duced combination of shudil has good safety, which can improve the blood flow of the dorsal foot artery, intermittent claudication dis-tance, and 6-keto-PGF1 α level. |
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