| 张若冰,何艳秋,罗嘉彬,等.长链非编码 RNA在乳腺癌中的研究进展[J].安徽医药,2025,29(3):425-429. |
| 长链非编码 RNA在乳腺癌中的研究进展 |
| Research progress of lncRNA in breast cancer |
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| DOI：10.3969/j.issn.1009-6469.2025.03.001 |
| 中文关键词: 乳腺肿瘤 长链非编码 RNA 细胞增殖 细胞凋亡 生物学作用 临床应用 |
| 英文关键词: Breast neoplasms Long non-coding RNA Cell proliferation Apoptosis Biological effect Clinical application |
| 基金项目:河北省自然科学基金资助项目( H2021201028) |
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| 摘要点击次数: 557 |
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| 中文摘要: |
| 乳腺癌在我国女性恶性肿瘤中发病率最高，尽管治疗方式不断改进，仍有部分病人出现复发和远端转移， 5年生存率仅有 25%。所以，充分了解乳腺癌侵袭、迁移的潜在机制，开发出新的治疗方法，对于减少乳腺癌病人的转移尤为重要。大量证据表明，长链非编码 RNA(lncRNA)可以作为一种潜在的生物标志物，通过不同的调控机制介导乳腺癌的发生发展及临床诊治。因此，该研究系统地综述了 lncRNA在乳腺癌生物学过程及临床应用中的调控作用及分子机制；不仅为乳腺癌的辅助诊断、精准治疗及预后评估提供了新的视角，同时也进一步促进了精准医学在临床诊治中的发展。 |
| 英文摘要: |
| Breast cancer has the highest incidence among female malignant tumors in China. Despite the continuous improvement oftherapies, some patients still have recurrence and distal metastasis, and the 5-year survival rate is only 25%. So it is very important tofully understand the underlying mechanism of the occurrence and development of breast cancer and to develop new therapeutic meth-ods to reduce the metastasis of breast cancer. Plenty of evidence indicates that long non-coding RNA (lncRNA) can be used as a poten-tial biomarker to mediate the occurrence, development and clinical diagnosis and treatment of breast cancer through different regulato-ry mechanisms. Therefore, this paper systematically reviews the regulatory role and molecular mechanism of lncRNA in the biologicalprocess and clinical application of breast cancer. It not only provides a new idea for auxiliary diagnosis, precision treatment and progno-sis assessment of breast cancer, but also further promotes the development of precision medicine in clinical diagnosis and treatment. |
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