| 陈亚君,刘虹.远端气道干细胞在肺损伤修复及病理性重塑中的研究进展[J].安徽医药,2025,29(3):436-439. |
| 远端气道干细胞在肺损伤修复及病理性重塑中的研究进展 |
| Research progress of DASCs in lung injury repair and pathological remodeling |
| |
| DOI：10.3969/j.issn.1009-6469.2025.03.003 |
| 中文关键词: 肺损伤 气道重塑 肺纤维化 肺再生 成体干细胞 |
| 英文关键词: Lung injury Airway remodeling Pulmonary fibrosis Lung regeneration Adult stem cells |
| 基金项目:山西省自然科学基金资助项目(面上项目)(201901D111360) |
|
| 摘要点击次数: 462 |
| 全文下载次数: 191 |
| 中文摘要: |
| 远端气道干细胞( DASCs)是远端呼吸道中一种表达肿瘤蛋白 -63(p63)和角蛋白 -5(Krt5)的成体肺干细胞。研究发现， DASCs可以特定植入受损的肺区域，通过再生远端气道上皮细胞或减轻炎症反应等机制促进肺损伤修复。此外， DASCs也与肺部病理性重塑密切相关，例如肺慢性炎症及纤维化。该研究综述了 DASCs的来源、分离培养与生物学特性， DASCs修复肺损伤的机制及 DASCs与肺部病理性重塑的关系，以期为 DASCs治疗肺部疾病的深入研究提供理论依据。 |
| 英文摘要: |
| Distal airway stem cells (DASCs) are adult lung stem cells in the distal airways that express tumor protein-63 (p63) and ker-atin-5 (Krt5). DASCs have been found to be specifically implanted in damaged lung regions and promote lung injury repair throughmechanisms such as regenerating distal airway epithelial cells or attenuating inflammatory responses. In addition, DASCs are alsoclosely associated with pathological lung remodeling, such as chronic inflammation and fibrosis in the lungs. In this paper, we reviewthe origin, isolation culture and biological properties of DASCs, the mechanism of lung injury repair by DASCs and the relationship be-tween DASCs and pathological lung remodeling, with the aim of providing theoretical basis for the in-depth study of DASCs in the treat-ment of lung diseases. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
