| 王永康.1990-2021年中国唇腭裂疾病负担：一项流行病学趋势分析[J].安徽医药,待发表. |
| 1990-2021年中国唇腭裂疾病负担：一项流行病学趋势分析 |
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| 投稿时间：2025-03-15 录用日期：2025-04-10 |
| DOI： |
| 中文关键词: 唇腭裂 疾病负担 Joinpoint回归 流行病学趋势 |
| 英文关键词: |
| 基金项目:山西省中医药管理局科研项目 (2023ZYYA023) |
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| 摘要点击次数: 116 |
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| 中文摘要: |
| 摘要 目的：分析1990-2021年间我国唇腭裂疾病负担现状及变化趋势，综合文献回顾，分析影响唇腭裂流行病学趋势的社会、环境和医疗因素 。方法：中国唇腭裂数据来源于GBD数据库2021版，提取唇腭裂的患病率、发病率、死亡率及DALYs率，并计算EAPC以反映1999-2021年的变化趋势。利用Joinpoint软件，分析发病率和死亡率分段回归中的转折点。汇总并可视化中国和不同发展水平国家之间的唇腭裂疾病负担。结果：2021年中国唇腭裂患病人数约为41万人，患病率约为30.79/10万人。1999-2021年患病率、发病率、死亡率、伤残调整生命年率均下降。发病率分段回归的转折点是1999年和2006年，死亡率分段回归的转折点是1999年、2004年和2013年。2021年唇腭裂发病率为2.27/10万人，低于高SDI国家平均水平。DALYs率为3.56/10万人，与中SDI、中高SDI水平国家相近。结论：1990-2021年间，中国唇腭裂的发病率，死亡率呈现下降趋势，疾病负担逐步减轻。这一趋势得益于多项干预措施的综合作用，包括产前筛查的普及、孕期健康管理的加强、唇腭裂序列治疗的开展以及环境改善。 |
| 英文摘要: |
| Abstract Objective: To analyze the disease burden and temporal trends of cleft lip and palate (CLP) in China from 1990 to 2021, and identify socioeconomic, environmental, and healthcare factors influencing epidemiological patterns through comprehensive literature review. Methods: CLP data were extracted from the Global Burden of Disease Study 2021 database. We calculated prevalence, incidence, mortality, and disability-adjusted life years (DALYs) rates, with estimated annual percentage changes (EAPC) used to quantify trends from 1999 to 2021. Joinpoint regression analysis identified turning points in incidence and mortality trends. Comparative visualization of China's CLP burden was conducted against countries with varying sociodemographic index (SDI) levels. Results: In 2021, China reported approximately 410,000 cases of cleft lip and/or palate (CL/P), with a prevalence rate of 30.79 per 100,000 population. A consistent downward trend was observed from 1999 to 2021 across multiple epidemiological indicators, including prevalence, incidence, mortality, and disability-adjusted life years (DALYs) rates. Segmented regression analysis revealed joinpoints in incidence rate trends during 1999 and 2006, while mortality rate trends exhibited turning points in 1999, 2004, and 2013. The 2021 CL/P incidence rate (2.27 per 100,000 population) was notably lower than the average levels in high-SDI countries. The corresponding DALYs rate (3.56 per 100,000 population) demonstrated comparability with national averages observed in middle-SDI and middle-high-SDI country groups. Conclusion: Between 1990 and 2021, the incidence and mortality rates of orofacial clefts in China have demonstrated a declining trend, accompanied by a gradual reduction in disease burden. This pattern can be attributed to the synergistic effects of various interventions, including the widespread implementation of prenatal screening, enhanced maternal health management, the establishment of treatment protocols for orofacial clefts, and improvements in environmental conditions. |
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