| 杨冰倩,廖立.参与牙发育和再生调控的关键机理[J].安徽医药,待发表. |
| 参与牙发育和再生调控的关键机理 |
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| 投稿时间：2025-03-31 录用日期：2025-04-30 |
| DOI： |
| 中文关键词: 牙发育 信号网络 干细胞 组织工程 |
| 英文关键词: |
| 基金项目:四川省科技计划项目,(项目编号：2023YFS0056)。 |
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| 摘要点击次数: 15 |
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| 中文摘要: |
| 牙齿发育是一种典型的器官形态发生模型，由复杂的上皮-间充质相互作用通过时空调节的信号网络驱动。尽管人类牙齿与其他外胚层附属器具有相同的发育机制，但其再生能力有限，给牙缺失的治疗带来了巨大的临床挑战。本文系统总结了近年来牙发生的分子和细胞机制，重点阐述了阶段特异性调控的动态变化。包括BMP、FGF、Wnt和sh在内的关键信号通路与Msx1、Pitx2和NFIC等转录因子相互作用。新兴的单细胞和空间转录组学研究揭示了新的祖细胞群体，从而完善了我们对谱系组成和细胞相互作用的理解。此外，我们还重点介绍了在口腔生物工程方面的突破。通过连接发育生物学和再生策略，这项工作为推进临床牙齿再生和对抗牙齿疾病提供了思路。 |
| 英文摘要: |
| Tooth development serves as a classic model of organ morphogenesis, driven by complex epithelial-mesenchymal interactions through spatiotemporally regulated signaling networks. Although human teeth share developmental mechanisms with other ectodermal appendages, their limited regenerative capacity poses significant clinical challenges for treating tooth loss. This review systematically summarizes recent advances in the molecular and cellular mechanisms underlying odontogenesis, with particular emphasis on stage-specific regulatory dynamics. Key signaling pathways including BMP, FGF, WNT, and Shh interact with transcription factors such as Msx1, Pitx2, and NFIC to orchestrate developmental processes. Emerging single-cell and spatial transcriptomic studies have unveiled novel progenitor cell populations, refining our understanding of lineage composition and cellular crosstalk. Furthermore, we highlight breakthroughs in tissue engineering approaches. By bridging developmental biology and regenerative strategies, this work provides insights for advancing clinical tooth regeneration and combating dental pathologies. |
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