| 赵璐,孙兴伟,王婷婷,等.三间隙引流术对高位肛周脓肿病人肛门功能、创面愈合及血清激活素 A水平的影响[J].安徽医药,2025,29(3):596-599. |
| 三间隙引流术对高位肛周脓肿病人肛门功能、创面愈合及血清激活素 A水平的影响 |
| Impacts of three space drainage on anal function, wound healing and serum ACTA level in patients with high perianal abscess |
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| DOI：10.3969/j.issn.1009-6469.2025.03.033 |
| 中文关键词: 肛周脓肿 三间隙引流术 肛门功能 创面愈合 激活素 A |
| 英文关键词: Perianal abscess Three space drainage Anal function Wound healing Activin A |
| 基金项目:陕西省重点研发计划项目( 2022SF-369) |
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| 中文摘要: |
| 目的探究三间隙引流术对高位肛周脓肿病人肛门功能、创面愈合及血清激活素 A(ACTA)水平的影响。方法纳入西北大学第一医院 2020年 10月至 2022年 10月收治的 48例高位肛周脓肿病人，依照治疗方案分为研究组和对照组，各 24例。对照组病人行传统切开引流术，研究组行三间隙引流术。比较两组病人创面愈合时间、住院时间、术后视觉模拟评分法( VAS)评分及术后肛门功能；比较两组病人手术前后血清炎症因子、疼痛因子及 ACTA水平变化。结果研究组术后创口愈合时间［( 18.25±2.36)d比( 22.25±3.12)d］、住院时间均较对照组缩短(均 P<0.05)；研究组术后 7 d VAS评分低于对照组( P<0.05)。协方差主体间效应检验显示，研究组病人血清 5-羟色胺( 5-HT)、去甲肾上腺素( NE)水平较对照组降低(均 P<0.05)；术后 7d研究组 Wexner量表评分［(7.07±0.97)分比( 9.47±1.49)分］低于对照组( P<0.05)。术后 7d研究组血清白细胞介素( IL)-1β、C反应蛋白( CRP)、 IL-6、肿瘤坏死因子 α(TNF-α)、 ACTA［(8.07±1.07)μg/L比( 13.08±1.07)μg/L］水平较对照组降低(均 P<0.05)；两组并发症发生率比较差异无统计学意义( P>0.05)。结论三间隙引流术创面小，可有效缓解病人疼痛，减轻炎症反应，降低 ACTA水平及相关并发症发生率，保留肛门功能，改善病人术后生活质量。 |
| 英文摘要: |
| Objective To explore the impact of three space drainage on anal function, wound healing and serum activin A (ACTA)level in patients with high perianal abscess.Methods Forty-eight patients with high perianal abscess admitted to Northwest Universi-ty First Hospital from October 2020 to October 2022 were included and assigned, according to the treatment plan, into a study groupand a control group, each with 24 cases. Patients in the control group received conventional incision and drainage, while patients inthe study group received three space drainage. A comparison was made of the wound healing time, hospitalization time, postoperativevisual analogue scale (VAS) score and postoperative anal function between the two groups; the levels of serum inflammatory factors,pain factors and ACTA were compared between the two groups before and after surgery.Results The wound healing time [(18.25± 2.36) d vs. (22.25±3.12) d] and hospital stay in the study group were shorter than those in the control group (both P<0.05); the VAS score of the study group on the 7th day after surgery was significantly lower than that of the control group (P<0.05). The covariance in-ter subject effect test results showed that the levels of serum serotonin (5-HT) and norepinephrine (NE) in the study group were signifi-cantly lower than those in the control group (both P<0.05); on the 7th day after surgery, the Wexner scale score in the study group waslower than that in the control group [(7.07±0.97) points vs. (9.47±1.49) points, P<0.05]. The levels of serum interleukin-1β (IL-1β), C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and ACTA [(8.07±1.07)μg/L vs. (13.08±1.07)μg/L] in the study group were lower than those in the control group 7 days after surgery (all P<0.05); there was no statistically significant differ-ence in the incidence of postoperative complications between the two groups (P>0.05).Conclusion Three space drainage has smallwound, which can effectively relieve the pain of patients, reduce the incidence of inflammatory reaction and related complications, pre-serve anal function, and improve the quality of life of patients after surgery. |
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