| 赵利敏,白睿华,王志永,等.涎腺分泌性癌 5例临床病理及预后分析[J].安徽医药,2025,29(3):600-603. |
| 涎腺分泌性癌 5例临床病理及预后分析 |
| Secretory carcinoma of salivary gland: a clinicopathological and prognosis analysis of 5 cases |
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| DOI：10.3969/j.issn.1009-6469.2025.03.034 |
| 中文关键词: 涎腺肿瘤 广谱细胞角蛋白 神经特异性蛋白 GATA结合蛋白 -3 钙调理蛋白 酪氨酸激酶生长因子受体 鉴别诊断 预后 |
| 英文关键词: Salivary gland neoplasms Cytokeratin Neuron-specific protein GATA binding protein-3 Calponin Growth fac-tor receptor tyrosine kinase Differential diagnosis Prognosis |
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| 中文摘要: |
| 目的探讨涎腺分泌性癌( SCSG)的临床病理学特征、免疫表型、分子病理学特征、诊断及预后。方法收集 2019年 12月至 2023年 2月郑州市第一人民医院及河南省肿瘤医院病理科诊断 SCSG 5例病人的临床病理资料，采用苏木精 -伊红( HE)、免疫组织化学染色及荧光原位杂交( FISH)进行病理学观察。结果 5例中男 2例，女 3例，年龄范围 6~73岁； 4例病变位于腮腺， 1例位于上唇，临床多无明显诱因出现面部肿物前来就诊；镜下肿瘤腔内可见嗜酸性均质分泌物，细胞核大小相对一致，胞浆丰富，偶见核分裂象。免疫表型: 5例肿瘤细胞广谱细胞角蛋白(CK)、细胞角蛋白 7(CK7)、乳腺球蛋白( Mammaglobin)、神经特异性蛋白( S-100)、 GATA结合蛋白 -3(GATA-3)阳性，波形蛋白( Vimentin)及上皮膜蛋白( EMA)部分阳性，钙调理蛋白( Cal-ponin)、酪氨酸激酶生长因子受体( CD117)、 DOG-1、P63阴性、 Ki67(5%~20%+)。 5例中 3例进行了 ETV6-NTRK3基因融合检测，均为阳性。 5例均进行了手术切除，其中 1例进行了放疗；随访 5例病人无瘤生存(分别随访 10、16、34、38、46个月)。结论 SCSG属于较为罕见的低度恶性涎腺肿瘤，易误诊为其他恶性肿瘤，免疫组织化学标志物及 ETV6-NTRK3基因检测的联合应用对 SCSG的诊断及治疗有较大价值。 |
| 英文摘要: |
| Objective To investigate the clinicopathological features, immunophenotype, molecular pathological characteristics, diag-noses and prognosis of secretory carcinoma of salivary gland (SCSG).Methods Clinicopathological data of 5 patients with SCSG diag-nosed in the Department of Pathology of The First People's Hospital of Zhengzhou and Henan Cancer Hospital from December 2019 toFebruary 2023 were collected. Hematoxylin-eosin (HE) staining, immunohistochemical staining and fluorescence in situ hybridization(FISH) were used for pathological observation.Results Among the 5 patients, 2 were male and 3 were female, with an age range of 6-73 years. Four lesions were located in the parotid gland, and one in the upper lip. Clinically, the patients mostly sought medical treat-ment because of facial masses without obvious inducement. Microscopically, homogeneous eosinophilic secretion was visible in the lu-men. The nuclei were relatively uniform in size. The cytoplasm was rich and occasionally showed nuclear division. Immunohistochemi-cally, generalized cytokeratin (CK), CK7, Mammaglobin, neuron-specific protein (S-100), and GATA binding protein-3 (GATA-3) werepositive , and Vimentin and epithelial membrane antigen (EMA) were partially positive in tumor cells of the 5 cases. Calponin, growthfactor receptor tyrosine kinase (CD117), DOG-1, and P63 were negative. Ki67 was positive in 5%-20% of tumor cells. Among the 5 cas-es, 3 cases were detected for ETV6-NTRK3 gene fusion, which were all positive. Five patients all underwent surgical resection, amongwhich 1 patient received radiotherapy. During follow-up, all the 5 patients had no tumor survival (followed up for 10, 16, 34, 38, and 46 months).Conclusion SCSG is a rare low-grade malignant salivary gland tumor which is easy to be misdiagnosed as other malignan-cies. The combined application of immunohistochemical marker and ETV6-NTRK3 gene detection is of great value for the diagnosis and treatment of SCSG. |
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