| 陈武羲,李昱萱,韦东君,等.彩色多普勒血流分级与周围型肺癌微血管密度相关性的初步研究[J].安徽医药,2025,29(3):620-623. |
| 彩色多普勒血流分级与周围型肺癌微血管密度相关性的初步研究 |
| Correlations between color Doppler blood flow grades and micro vessel density in peripheral lung cancer: a preliminary study |
| |
| DOI：10.3969/j.issn.1009-6469.2025.03.039 |
| 中文关键词: 肺肿瘤 超声检查，多普勒，彩色 局部血流 血流分级 微血管密度 |
| 英文关键词: Lung neoplasms Ultrasonography, Doppler, color Regional blood flow Blood flow grade Micro vessel density |
| 基金项目: |
|
| 摘要点击次数: 261 |
| 全文下载次数: 168 |
| 中文摘要: |
| 目的初步探讨彩色多普勒血流分级与周围型肺癌微血管密度的相关性及线性关系，为后续超声及时评价动态监测肺癌疗效的进一步研究打下基础。方法回顾性分析 2020年 1月至 2022年 3月广州医科大学附属第一医院 105例行超声引导肺穿刺活检证实为肺癌的病人相关资料。在穿刺活检前对病灶行彩色多普勒血流显像( CDFI)并将病灶血流丰富程度分为 0~Ⅲ级；随后对病灶行超声引导下的穿刺活检，对所取标本行组织病理学检测及 CD34免疫组织化，学染色，计数病灶的微血管密度( MVD)并探讨 CDFI血流分级与 MVD的相关性及线性关系。结果 105例病人中，病灶最大径: ≤5 cm者 34例、 >5 cm者 71例； CDFI血流，分级: 0级 4例、 Ⅰ级 25例、 Ⅱ级 28例、 Ⅲ级 48例； Mann-Whitney U检验显示， ≤5 cm组与 >5 cm组 MVD差异无统计学意义； Spearman相关分析显示血流分级与 MVD具有正相关关系( rs=0.31，P<0.001)；简单线性回归分析示血流分级与 MVD存在线性关系，(F=14.55，P<0.001)，回归方程: MVD=18.349+4.990×血流分级(r2=0.12)。结论彩色多普勒血流分级与周围型 |
| 英文摘要: |
| Objective To discuss the correlations between color Doppler blood flow grades and micro vessel density (MVD) in periph-eral lung cancer, to lay a foundation for the further research on the timely evaluation and dynamic monitoring of the therapeutic effect oflung cancer by using ultrasound.Methods The relevant data of 105 patients diagnosed with lung cancer through ultrasound-guidedlung biopsy at the First Affiliated Hospital of Guangzhou Medical University from January 2020 to March 2022 were retrospectively an-alyzed. Color Doppler flow imaging (CDFI) examination was performed on the lesion before biopsy procedure, and the blood flow of thelesion was graded into 4 grades (from grade 0 to grade Ⅲ); and then ultrasound guided lung biopsy was performed on the lesion, thesamples of the lesion were sent to made histopathological as well as CD34 immunohistochemical examinations, the microvessel density(MVD) of the lesion was counted, and then the correlations between blood flow grades and MVD in peripheral lung cancer were dis-cussed.Results Among 105 cases, there were 34 cases with the maximum diameter of the lesion being ≤5 cm, and 71 cases being >5cm. The distribution of blood flow grades: 4 cases with grade 0, 25 cases with grade I, 28 cases with grade Ⅱ, 48 cases with grade Ⅲ.Mann-Whitney U test showed that there was no significant differences in MVD between the ≤5 cm group and >5 cm group; Spearmancorrelation analysis showed that there were positive correlations between blood flow grades and MVD (r=0.31, P<0.001). Simple linear |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
