| 李光宇,周庆,李宏达,等.间充质干细胞来源外泌体在肝纤维化中的治疗机制[J].安徽医药,2025,29(4):641-647. |
| 间充质干细胞来源外泌体在肝纤维化中的治疗机制 |
| Research of mesenchymal stem cell-derived exosomes in the treatment of liver fibrosis |
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| DOI：10.3969/j.issn.1009-6469.2025.04.002 |
| 中文关键词: 肝纤维化 间充质干细胞 外泌体 无细胞疗法 治疗机制 |
| 英文关键词: Liver fibrosis Mesenchymal stem cells Exosomes Cell-free therapy Therapeutic mechanism |
| 基金项目:镇江市重点研发计划(社会发展)项目( SH2020027) |
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| 摘要点击次数: 328 |
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| 中文摘要: |
| 肝纤维化以瘢痕形成为特征，是由慢性肝损伤向肝癌转变的中间病理过程。间充质干细胞( mesenchymal stem cells， MSCs)具备多向分化潜能，可参与多种疾病的损伤修复过程。 MSCs来源的外泌体治疗肝纤维化是一种新兴的治疗方式，具备传统 MSCs移植治疗的优点。目前较多研究关注于分析 MSCs外泌体所含成分对于肝纤维化的治疗机制，其在细胞实验及动物实验中已取得一定成果。以 MSCs外泌体为主的无细胞疗法是未来肝纤维化治疗的研究趋势。 |
| 英文摘要: |
| Hepatic fibrosis, characterized by scar formation, is an intermediate pathological process from chronic liver injury to livercancer. Mesenchymal stem cells (MSCs), possessing multi-directional differentiation potential, can participate in the repair process of various diseases. MSCs-derived extracellular vesicles (MSCs-Ex) have emerged as a novel therapeutic approach for the treatment of liv.er fibrosis, with advantages over traditional MSCs transplantation. Currently, many studies focus on analyzing the therapeutic mecha.nism of MSCs-Ex in liver fibrosis by identifying its components, and some progress has been made in cell and animal experiments. Cell-free therapy based on MSCs-Ex is a research trend for the treatment of liver fibrosis in the future. |
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