曹又文,马江涛,郑江华.药物通过沉默信息调节因子 1调控动脉粥样硬化的研究进展[J].安徽医药,2025,29(4):654-660. |
药物通过沉默信息调节因子 1调控动脉粥样硬化的研究进展 |
Research progress of drugs regulating atherosclerosis by silencing information regulator 1 |
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DOI:10.3969/j.issn.1009-6469.2025.04.004 |
中文关键词: 沉默信息调节因子 1 抗动脉粥样硬化药 动脉粥样硬化 研究进展 综述 |
英文关键词: Silent information regulator1 Antiatherosclerotics Atherosclerosis Research progress Review |
基金项目:南充市市校科技战略合作专项基金项目( 20SXZRKX0009);川北医学院附属医院院内基金项目( 2020ZD012) |
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中文摘要: |
动脉粥样硬化( atherosclerosis,AS)的预防和治疗,一直是近年来的研究热点。越来越多的研究表明,沉默信息调节因子 1(silent information regulator1,Sirt1)在 AS的发生与发展过程中起着重要作用。找到能够通过 Sirt1调控 AS的药物以预防和治疗 AS便具有重要的意义。该研究对 Sirt1进行概述,并对近年来药物通过 Sirt1调控 AS的研究进展进行综述,以期为 AS的进一步研究及治疗提供部分思路。 |
英文摘要: |
The prevention and treatment of atherosclerosis (AS) has been a research hotspot in recent years. More and more studieshave shown that silent information regulator 1 (Sirt1) plays an important role in the occurrence and development of AS. It is of great sig.nificance to find drugs that can regulate AS through Sirt1 to prevent and treat AS. This study provides a summary of Sirt1 and reviewsthe research progress in the regulation of AS by drugs through Sirt1 in recent years, so as to provide some ideas for further research andtreatment of AS. |
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