| 尹延肖.成人新发癫痫患者VILIP-1、BAFF、Lp-PLA2交互作用对认知功能障碍风险的影响[J].安徽医药,待发表. |
| 成人新发癫痫患者VILIP-1、BAFF、Lp-PLA2交互作用对认知功能障碍风险的影响 |
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| 投稿时间：2025-04-11 录用日期：2025-07-03 |
| DOI： |
| 中文关键词: 癫痫 新发 成人 视锥蛋白样蛋白-1 B细胞活化因子 脂蛋白相关磷脂酶A2 认知功能障碍 |
| 英文关键词: |
| 基金项目:邯郸市科学技术研究与发展计划项目（23422083276） |
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| 摘要点击次数: 17 |
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| 中文摘要: |
| 目的 探究成人新发癫痫患者视锥蛋白样蛋白-1（VILIP-1）、B细胞活化因子（BAFF）、脂蛋白相关磷脂酶A2（Lp-PLA2）交互作用对认知功能障碍风险的影响。方法 选取2023年8月～2024年8月邯郸市第一医院229例成人新发癫痫患者进行前瞻性研究，根据患者有无认知障碍分为认知障碍组（n=70）与认知正常组（n=159），比较两组一般资料及血清VILIP-1、BAFF、Lp-PLA2水平，分析成人新发癫痫患者认知功能障碍风险因素及血清VILIP-1、BAFF、Lp-PLA2交互作用对认知功能障碍风险的影响。结果 认知障碍组脑电图背景节律减慢、脑电图发作间期痫样放电占比、发作频率及血清VILIP-1、BAFF、Lp-PLA2水平高于认知正常组（P＜0.05）；Logistic回归分析，结果显示，发作频率、脑电图背景节律减慢、脑电图发作间期痫样放电及血清VILIP-1、BAFF、Lp-PLA2水平均为成人新发癫痫患者认知功能障碍的独立影响因素（P＜0.05）；限制性立方样条（RCS）模型分析显示，调整其他混杂因素后，成人新发癫痫患者血清VILIP-1、BAFF、Lp-PLA2水平与认知功能障碍风险呈非线性关系（P＜0.05），当成人新发癫痫患者VILIP-1≥473.00 pg/mL、BAFF≥9.00 ng/mL、Lp-PLA2≥45.00 μg/L时，认知功能障碍风险均随着其水平升高呈上升趋势（P＜0.05）；交互作用分析显示，在调整协变量前后血清VILIP-1、BAFF、Lp-PLA2对成人新发癫痫患者认知功能障碍风险存在协同作用（P＜0.05）。结论 成人新发癫痫患者血清VILIP-1、BAFF、Lp-PLA2水平升高与认知功能障碍密切相关，且三者对认知功能障碍风险存在协同作用，或可为新发癫痫患者认知功能障碍预测及防治治疗新思路。 |
| 英文摘要: |
| Objective ?To investigate the effect of the interaction among Visinin-like protein 1 (VILIP-1), B cell activating factor (BAFF) and lipoprotein-associated phospholipase A2 (Lp-PLA2) on the risk of cognitive dysfunction in adult patients with new-onset epilepsy. Methods ?A prospective study was conducted on 229 adult patients with new-onset epilepsy in Handan First Hospital from August 2023 to August 2024. Patients were divided into cognitive dysfunction group (n=70) and cognitive normal group (n=159) according to whether they had cognitive impairment. The general data and serum levels of VILIP-1, BAFF, and Lp-PLA2 were compared between the two groups, and the risk factors of cognitive dysfunctionin adult patients with new-onset epilepsy and the interaction of serum VILIP-1, BAFF, and Lp-PLA2 on the risk of cognitive dysfunction were analyzed. Results ?The cognitive dysfunctiongroup had slower background rhythms in electroencephalogram, higher proportions of epileptiform discharges during interictal periods, seizure frequency, and higher levels of serum VILIP-1, BAFF, and Lp-PLA2 than the cognitive normal group (P<0.05). Logistic regression analysis showed that seizure frequency, slowing of EEG background rhythm, interictal epileptiform discharges on EEG, and serum levels of VILIP-1, BAFF, and Lp-PLA2 were independent factors affecting cognitive dysfunction in adult patients with new-onset epilepsy (P<0.05); the analysis of the Restricted Cubic Spline (RCS) model showed that after adjusting for other confounding factors, the levels of serum VILIP-1, BAFF, and Lp-PLA2 in adult patients with new-onset epilepsy were nonlinearly related to the risk of cognitive dysfunction (P<0.05). When the levels of VILIP-1 in adult patients with new-onset epilepsy were ≥473.00 pg/mL, BAFF ≥9.00 ng/mL, and Lp-PLA2 ≥45.00 μg/L, the risk of cognitive dysfunction increased with their levels (P<0.05). Interaction analysis showed that serum VILIP-1, BAFF, and Lp-PLA2 had a synergistic effect on the risk of cognitive dysfunction in adult patients with new-onset epilepsy before and after adjusting for covariates (P<0.05). Conclusion ?The elevated levels of serum VILIP-1, BAFF, and Lp-PLA2 in adult patients with new-onset epilepsy are closely related to cognitive dysfunction, and the three have a synergistic effect on the risk of cognitive dysfunction. This may provide a new idea for predicting, preventing, and treating cognitive dysfunction in patients with new-onset epilepsy. |
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