| 徐晓蝶,张迈,丁华,等.原发性乳腺神经内分泌癌 1例报告并文献复习[J].安徽医药,2025,29(4):696-699. |
| 原发性乳腺神经内分泌癌 1例报告并文献复习 |
| Primary neuroendocrine carcinoma with bone metastasis: a case report and literature review |
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| DOI：10.3969/j.issn.1009-6469.2025.04.012 |
| 中文关键词: 乳腺肿瘤 神经内分泌癌 骨转移 新辅助治疗 病例报告 |
| 英文关键词: Breast neoplasms Neuroendocrine carcinoma Bone metastasis Neoadjuvant therapy Case reports |
| 基金项目:国家自然科学基金资助项目( 82060480)；国家卫生健康委资助项目( RCLX2315097) |
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| 中文摘要: |
| 目的结合文献报告 1例原发性神经内分泌癌并骨转移病例。方法总结 2020年 3月贵州医科大学附属医院收治的 1例女性原发性神经内分泌癌并骨转移病人病例资料，并进行相关文献复习。结果病人因发现右乳包块 3余年收治入院，行右乳肿物穿刺活检，病理证实:右乳神经内分泌癌。临床分期 cT3N1M1Ⅳ期，人表皮生长因子受体 -2(human epidermal growth factor receptor 2，HER2)扩增区域 20%。予 4周期表柔比星联合环磷酰胺( AC)新辅助化疗后疗效不佳，考虑病人 HER2基因异质性，后予 4周期多西他赛联合曲妥珠单抗联合帕妥珠单抗( THP)继续新辅助治疗，疗效评估为疾病稳定( stable disease，SD)，行姑息性右乳切除术，术后 1个月胸壁局部复发，术后 1年病人全身多处转移后死亡。结论原发性乳腺神经内分泌肿瘤极为罕见，目前尚无确切诊疗标准，预后不一，其治疗遵循乳腺癌的综合治疗原则。 |
| 英文摘要: |
| Objective To report a case of primary neuroendocrine carcinoma with bone metastasis combined with literature review. Methods The clinical data of a female patient diagnosed with primary neuroendocrine carcinoma and bone metastasis admitted to theAffiliated Hospital of Guizhou Medical University in March 2020 were summarized, and the related literature was reviewed. Results The patient was admitted to the hospital due to the presence of a right breast mass discovered over 3 years ago. A needle biopsy was per.formed on the mass, revealing CT3N1M1 stage Ⅳ disease (human epidermal growth factor receptor 2, HER2) amplification area 20%.The response was poor after 4 cycles of epirubicin combined with cyclophosphamide (AC) neoadjuvant chemotherapy. Considering theheterogeneity of HER2 gene, the patient received 4 cycles of Docetaxel plus trastuzumab combined with pertuzumab (THP) neoadju.vant therapy, with a response evaluated as stable disease (SD). A palliative right mastectomy was performed after neoadjuvant therapy.However, 1 month after surgery, local recurrence occurred in the chest wall. The patient died of multiple metastases 1 year after surgery.Conclusions Primary neuroendocrine tumors of the breast are extremely rare and lack definitive diagnostic criteria and treatmentstandards at present. The prognosis of primary neuroendocrine tumors varies, whose treatment follows the principle of comprehensivetreatment of breast cancer. |
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