| 张雅,马云龙,王璐鹏.中医序贯疗法配合射频消融术治疗下肢静脉溃疡 30例疗效[J].安徽医药,2025,29(4):768-772. |
| 中医序贯疗法配合射频消融术治疗下肢静脉溃疡 30例疗效 |
| Curative effect of sequential therapy of traditional Chinese medicine combined with radiofrequency ablation on venous leg ulcers: a report of 30 cases |
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| DOI：10.3969/j.issn.1009-6469.2025.04.027 |
| 中文关键词: 静脉曲张溃疡 下肢 中医序贯疗法 射频消融术 核因子 κB p65 核因子 κB抑制蛋白 α |
| 英文关键词: Varicose ulcer Lower extremity Sequential therapy of traditional Chinese medicine Radiofrequency ablation Nuclear factor κB p65 Inhibitory protein -κB |
| 基金项目:中医药类科研计划课题项目( 2019011) |
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| 中文摘要: |
| 目的探究中医序贯疗法配合射频消融术治疗下肢静脉溃疡的效果。方法该研究为前瞻性随机对照研究，采用随机抽样法选取 2019年 1月至 2021年 12月河北省中医院 60例下肢静脉溃疡病人，依据随机数字表法将其分为对照组(30例)与研究组( 30例)对照组采用射频消融术治疗，研究组在对照组基础上联合中医序贯疗法。观察两组临床疗效，对比两组治疗前、治疗 2周时溃疡，面积、静脉临床炎症程度评分( VCSS)、炎症因子水平及核因子 κB p65(NF-κB p65)、核因子 κB抑制蛋白 α(IκBα)水平；随访 6个月，统计复发率。结果治疗 2周时，研究组治疗总有效率比对照组高，溃疡面积( 0.62±0.28)cm2比对照(1.04±0.43)cm2小， VCSS(3.28±1.36)分、肿瘤坏死因子 α(TNF-α)(12.57±3.46)ng/L、白细胞介素(IL)-1β(26.35±6.79)ng/L、IL-6(组33.64±8.12)ng/L、NF-κBp65水平( 0.75±0.21)比对照组( 5.31±1.85)分、(16.94±4.18)ng/L、(32.17±6.25)ng/L、(39.54±9.27)ng/ L、(0.98±0.30)低， IκBα水平( 1.74±0.56)比对照组( 1.45±0.41)高( P<0.05)；随访 6个月，研究组复发率( 23.33%)比对照组(50.00%)低( P<0.05)。结论中医序贯疗法配合射频消融术能够调节下肢静脉溃疡病人 NF-κBp65、IκBα及炎症因子水平，减轻静脉临床炎症程度，缩小溃疡面积，提高临床疗效。 |
| 英文摘要: |
| Objective To explore the effect of sequential therapy of traditional Chinese medicine combined with radiofrequency abla.tion on venous leg ulcers.Methods This study was a prospective randomized controlled study. A total of 60 patients with venous legulcers treated in Hebei Hospital of Traditional Chinese Medicine from January 2019 to December 2021 were selected and assigned intocontrol group (n=30) and study group (n=30) according to random number table method. The control group was treated with radiofre.quency ablation, while the study group was treated with sequential therapy of traditional Chinese medicine in addition to radiofrequen.cy ablation. The clinical effects of the two groups were observed. A comparison was made of the ulcer area, venous clinical severityscore (VCSS), inflammatory factors, and the levels of nuclear factor κB p65 (NF-κBp65) and inhibitor protein κB (IκBα) before treat. ment and two weeks after treatment. Follow-up was carried out for 6 months to figure out the recurrence rate.Results After 2 weeks of treatment, the total effective rate of the study group was higher than that of the control group, and the ulcer area of the study group wassmaller than that of the control group [(0.62±0.28) cm2 vs. (1.04±0.43) cm2]. VCSS and the levels of TNF-α, IL-1β, IL-6, and NF-κBp65 (0.98±0.30) were lower in the study group than those in the control group [(3.28±1.36) points vs. (5.31±1.85) points, (12.57±3.46) ng/L vs. (16.94±4.18) ng/L, (26.35±6.79) ng/L vs. (32.17±6.25) ng/L, (33.64±8.12) ng/L vs. (39.54±9.27) ng/L, and (0.75±0.21) vs. (0.98± 0.30), respectively], while the level of IκBα was higher in the study group than that in the control group [(1.74±0.56) vs. (1.45±0.41)](P< 0.05). Six-month follow-up found that the recurrence rate of the study group (23.33%) was lower than that of the control group (50.00%) (P<0.05).Conclusion Sequential therapy of traditional Chinese medicine combined with radiofrequency ablation can regulate the lev. els of NF-κBp65, IκBα and inflammatory factors in patients with venous leg ulcers, relieve venous clinical inflammation, reduce the ar.ea of ulcer and therefore improve the clinical efficacy. |
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