| 张嘉雯,王椋.自体造血干细胞移植序贯 CD19/CD22嵌合抗原受体 T细胞治疗原发难治性弥漫大 B细胞淋巴瘤 1例并文献复习[J].安徽医药,2025,29(4):793-797. |
| 自体造血干细胞移植序贯 CD19/CD22嵌合抗原受体 T细胞治疗原发难治性弥漫大 B细胞淋巴瘤 1例并文献复习 |
| Autologous hematopoietic stem cell transplantation followed by sequential CD19/CD22 chimeric antigen receptor T cells for the treatment of primary refractory diffuse large B-cell lymphoma: a case report and literature review |
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| DOI：10.3969/j.issn.1009-6469.2025.04.033 |
| 中文关键词: 淋巴瘤，大 B细胞，弥漫性 序贯治疗 嵌合抗原受体 T细胞 自体造血干细胞移植 放疗 |
| 英文关键词: Lymphoma, large B-Cell, diffuse Sequential therapy Chimeric antigen receptor T cells Autologous hematopoietic stem cell transplantation Radiotherapy |
| 基金项目:山东省医药卫生科技发展计划项目( 202220304045414) |
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| 中文摘要: |
| 目的为原发难治性弥漫大 B细胞淋巴瘤治疗提供可能的思路。方法回顾性分析胜利油田中心医院于 2022年 9月 7日收治的 1例原发难治性弥漫大 B细胞淋巴瘤的临床资料并复习相关文献。结果该病人先后给予利妥昔单抗联合吡柔比星、环磷酰胺、长春地辛及泼尼松( R-CHOP)方案化疗 1疗程、利妥昔单抗联合多柔比星脂质体、环磷酰胺、长春地辛及泼尼松(R-CDOP)方案化疗 2个疗程后病情进展，后给予奥布替尼联合利妥昔单抗联合依托泊苷、异环磷酰胺及卡铂(奥布替尼 +R-ICE)方案治疗后腹腔仍可见大包块，放疗降低肿瘤负荷后行自体造血干细胞移植序贯 CD19/CD22嵌合抗原受体 T细胞治疗。过程中出现 2级细胞因子释放综合征经对症处理后症状缓解。后行 PET-CT评估疗效为完全代谢缓解。结论自体造血干细胞移植序贯 CD19/CD22嵌合抗原受体 T细胞是治疗原发难治性弥漫大 B细胞淋巴瘤的有效方法。 |
| 英文摘要: |
| Objective To provide reference for the treatment of primary refractory diffuse large B-cell lymphoma. Methods The clinical data of a case of primary refractory diffuse large B-cell lymphoma admitted to Shengli Oilfield Central Hospital on September 7,2022 were retrospectively analyzed and related literature was reviewed.Results The patient's condition worsened after 1 course ofchemotherapy with rituximab, pirarubicin, cyclophosphamide, vincristine and prednisone(R-CHOP) and 2 courses of chemotherapy with rituximab, doxorubicin liposomal, cyclophosphamide, vincristine and prednisone(R-CDOP). After treatment with aubutinib, ritux. imab, etoposide, ifosfamide, carboplatin (aubutinib plus R-ICE), large masses were still visible in the abdominal cavity. Autologous he.matopoietic stem cell transplantation followed by sequential CD19/CD22 chimeric antigen receptor T cell therapy was performed afterradiotherapy to reduce tumor load. Grade 2 cytokine release syndrome appeared during the therapeutic process, and the symptoms wererelieved after symptomatic treatment. PET-CT evaluation indicated complete metabolic remission.Conclusion Autologous hematopoi.etic stem cell transplantation followed by sequential CD19/CD22 chimeric antigen receptor T cells is an effective therapy for primary re.fractory diffuse large B-cell lymphoma. |
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