| 高旭,刘会领,王昕,等.血小板参数对超低出生体质量儿支气管肺发育不良的预测价值[J].安徽医药,2025,29(4):810-814. |
| 血小板参数对超低出生体质量儿支气管肺发育不良的预测价值 |
| Predictive value of platelet parameters for bronchopulmonary dysplasia in extremely low birth weight infants |
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| DOI：10.3969/j.issn.1009-6469.2025.04.036 |
| 中文关键词: 超低出生体质量儿 支气管肺发育不良 血小板参数 早产儿 机械通气 |
| 英文关键词: Extremely low birth weight infants Bronchopulmonary dysplasia Platelet parameters Premature Mechanical ven. tilation |
| 基金项目:沧州市科技计划自筹经费项目( 23244102021) |
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| 中文摘要: |
| 目的探讨血小板参数对超低出生体质量儿( ELBW)支气管肺发育不良的预测价值。方法回顾性分析沧州市人民医院 2019年 11月至 2023年 6月收治的，在出生后 2h内转至新生儿重症监护室( NICU)且体质量低于 1 000 g、住院时间 ≥28 d的 ELBW的临床资料。据入组 ELBW是否患支气管肺发育不良( BPD)分为 BPD组与非 BPD组。收集整理纳入研究的 ELBW的一般临床资料及不同时间点血小板计数、血小板压积(PCT)、血小板分布宽度( PDW)、平均血小板体积( MPV)。结果共纳入 ELBW 62例，其中 BPD组 24例，非 BPD组 38例。两组在胎龄、住院时间、机械通气时间、早产儿视网膜病变( ROP)发生率、母孕期高血压比例指标上差异有统计学意义( P<0.05)。 BPD组病儿生后第 2周末血小板计数为 199.50(149.50，239.00)×109/L高于非 BPD组第 2周末的 139.00(113.25，173.25)×109/L(P<0.05)。多因素 logistic回归分析结果表明，生后第 2周末血小板计数、住院时间及机械通气时间是 ELBW发生 BPD的独立危险因素( P<0.05)。 ROC曲线分析显示生后第 2周末血小板计数的最佳截断值为 180×109/L，曲线下面积 0.70，灵敏度 66.7%，特异度 71.1%，约登指数为 0.38；住院时间的最佳截断值为 83.5 d，曲线下面积 0.75，灵敏度 58.3%，特异度 86.8%，约登指数为 0.45；机械通气时间的最佳截断值为 191.5 h，曲线下面积 0.77，灵敏度 |
| 英文摘要: |
| Objective To explore the predictive value of platelet parameters in bronchopulmonary dysplasia in extremely low birth weight infants.Methods A retrospective analysis was performed for the clinical data of extremely low birth weight infants admitted toCangzhou People's Hospital from November 2019 to June 2023 and transferred to the neonatal intensive care unit (NICU) within 2hours after birth, with a weight of less than 1000 g and a hospital stay longer than or equal to 28 days. The babies were assigned intobronchopulmonary dysplasia (BPD) group and non-BPD group according to whether they had BPD or not. General clinical data andplatelet parameters at different time points, including platelet count, plateletcrit (PCT), platelet distribution width (PDW) and meanplatelet volume (MPV), were collected.Results A total of 62 extremely low birth weight infants were included in this study, including 24 in the BPD group and 38 in the non-BPD group. There were significant differences in gestational age, length of hospital stay, dura.tion of mechanical ventilation, incidence of retinopathy of prematurity (ROP) and proportion of maternal hypertension during pregnancybetween the two groups (P<0.05). The platelet count of the BPD group was significantly higher than that of the non-BPD group [199.50 (149.50, 239.00)×109/L vs. 139.00 (113.25,173.25)×109/L] at the end of the second week of life (P<0.05). The results of multivariate lo.gistic regression analysis showed that platelet count, length of hospital stay and duration of mechanical ventilation at the end of the sec.ond week of life were independent risk factors for BPD in extremely low birth weight infants (P<0.05). ROC curve analysis showed that at the end of the second week of life the optimal cut-off value of platelet count was 180×109/L, the area under the curve 0.70, the sensi. tivity 66.7%, the specificity 71.1%, and the Youden index 0.38; the optimal cut-off value of length of hospital stay was 83.5 d, the areaunder the curve 0.75, the sensitivity 58.3%, the specificity 86.8%, and the Youden index 0.45; the optimal cut-off value of mechanical ventilation time was 191.5 h, the area under the curve 0.77, the sensitivity 70.8%, the specificity 81.6%, and the Youden index 0.52.Conclusion Higher platelet count, longer hospital stay and duration of mechanical ventilation at the end of the second week of life were independent risk factors for BPD in extremely low birth weight infants, and platelet parameters had good predictive value for BPDin extremely low birth weight infants. |
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