| 陶婷,邹琦,韩国栋,等.丝裂原活化蛋白激酶通路在心肌缺血 /再灌注损伤中的作用机制及药物防治[J].安徽医药,2025,29(5):862-868. |
| 丝裂原活化蛋白激酶通路在心肌缺血 /再灌注损伤中的作用机制及药物防治 |
| Exploring the mechanism and drug prevention and treatment of myocardial ischemia/reperfusion injury based on mitogen-activated protein kinase pathway |
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| DOI：10.3969/j.issn.1009-6469.2025.05.003 |
| 中文关键词: 心肌再灌注损伤 丝裂原活化蛋白激酶通路 作用机制 药物防治 |
| 英文关键词: Myocardial reperfusion injury Mitogen-activated protein kinase pathway Mechanism of function Drug prevention and treatment |
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| 摘要点击次数: 102 |
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| 中文摘要: |
| 目前，心肌梗死( MI)的发病率和死亡率不断上升。其主要治疗方法包括经皮冠状动脉介入术、冠状动脉搭桥术和溶栓治疗。尽管上述治疗提高了心肌存活率，但它们也增加了心肌缺血 /再灌注损伤( MIRI)的风险。丝裂原活化蛋白激酶(MAPK)通路与心肌细胞凋亡、自噬和线粒体功能障碍密切相关，在缺血 /再灌注( I/R)损伤的发生发展中扮演着重要的角色。近年来众多研究显示，通过药物调控 MAPK通路可以有效缓解 MIRI。然而，目前仍缺乏该领域的系统性描述，现总结 MAPK通路在 MIRI中的作用机制及相关的靶向治疗药物，为 MIRI的防治提供理论依据。 |
| 英文摘要: |
| Currently,the incidence and mortality rate of myocardial infarction (MI) are on the rise.The main treatment methods includepercutaneous coronary intervention, coronary artery bypass grafting, and thrombolytic therapy. Although the above treatments have in-creased myocardial survival rates, they also elevate the risk of myocardial ischemia/reperfusion injury (MIRI). The Mitogen-activated protein kinase (MAPK) pathway is closely associated with myocardial cell apoptosis, autophagy, and mitochondrial dysfunction, playinga significant role in the occurrence and development of ischemia/reperfusion (I/R) injury. In recent years, numerous studies have shownthat drug modulation of the MAPK pathway can effectively alleviate myocardial ischemia/reperfusion injury. However, there is still alack of systematic description in this field. This study aims to provide a theoretical basis for the prevention and treatment of MIRI bysummarizing the mechanisms of action of the MAPK pathway in MIRI and related targeted therapeutic drugs. |
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