| 饶琴,闫理想,朱吉祥,等.脂代谢调控肿瘤免疫在急性髓系白血病中的研究进展[J].安徽医药,2025,29(5):888-892. |
| 脂代谢调控肿瘤免疫在急性髓系白血病中的研究进展 |
| Progress in lipid metabolism regulation of tumor immunity in AML |
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| DOI：10.3969/j.issn.1009-6469.2025.05.007 |
| 中文关键词: 急性髓系白血病 脂代谢重编程 肿瘤微环境 免疫抑制 |
| 英文关键词: Acute myeloid leukemia Reprogramming of lipid metabolism Tumor microenvironment Immunologic suppression |
| 基金项目:天津市教委自然科学计划项目( 2021KJ145) |
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| 中文摘要: |
| 脂代谢重编程是肿瘤新发现的标志，是肿瘤研究领域中新的热点之一。近年来的研究认识到，在肿瘤微环境中，脂质代谢的重新编程对于急性髓系白血病( AML)细胞具有信号分子和能量来源的作用，能够进一步影响机体的免疫机制。现重点阐述脂质代谢机制在 AML发病中的作用，脂代谢重编程调控耗竭性免疫细胞，免疫代谢有关药物的临床应用，以及当前的最新研究进展，以期为 AML的临床精准靶向治疗及获得更好的疾病预后提供新的思路。 |
| 英文摘要: |
| Lipid metabolism reprogramming is a hallmark of new cancer discoveries and one of the new hotspots in the field of cancerresearch. Studies in recent years have recognized that in the tumor microenvironment, the reprogramming of lipid metabolism has a sig-naling molecule and energy source for acute myeloid leukemia (AML) cells, which can further affect the body's immune mechanism.This paper focuses on the role of lipid metabolism mechanisms in the pathogenesis of AML, the reprogramming of lipid metabolism toregulate the depletion of immune cells, the clinical application of immune metabolism-related drugs, and the latest research progress,so as to provide new ideas for the clinical precision targeted therapy of AML and obtain better disease prognosis. |
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