| 樊嘉欣,郭兴志,曹帅,等.复合膳食抗氧化指数与卒中及其全因死亡率的关联研究[J].安徽医药,2025,29(5):949-957. |
| 复合膳食抗氧化指数与卒中及其全因死亡率的关联研究 |
| Associations of composite dietary antioxidant index with stroke and all-cause mortality in stroke |
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| DOI：10.3969/j.issn.1009-6469.2025.05.019 |
| 中文关键词: 复合膳食 卒中 抗氧化指数 全因死亡率 关联 |
| 英文关键词: Composite diet Stroke Antioxidant index All-cause mortality Association |
| 基金项目:陕西省自然科学基础研究计划青年项目( 2024JC-YBQN-0861)；陕西省社会卫生发展重点创新项目(2022ZDLSF04-06) |
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| 中文摘要: |
| 目的分析复合膳食抗氧化指数( CDAI)与卒中及其全因死亡率的关联。方法纳入国家健康和营养调查( NHANES) 2001―2018年的 43 210例成人数据分析。 CDAI依维生素 A、C、E、类胡萝卜素及锌、硒摄入量计算，按三分位法将人群分为 Low组、 Moderate组、 High组。采用多因素 logistic回归分析 CDAI与卒中的关联，采用 Cox比例风险模型分析 CDAI与卒中全因死亡率的关联。采用限制性三次样条( RCS)评估 CDAI与卒中及其全因死亡率关联的非线性关系，采用亚组分析评估关联效应的稳定性。结果 logistic回归分析表明，模型 1中的 High组人群的 OR值为 0.52［95%CI:(0.46，0.58)P<0.001］模型 2中的 OR值为 0.74［95%CI:(0.65，0.85)P<0.001］和模型 3中的 OR值为 0.79［95%CI:(0.68，0.92)P=0.002］。C，ox风险模型，表明，与 Low组相比， High组人群的全因死亡，风险分别降低了 28%［模型 1:HR=0.72，95%CI:(0.59，0.8，8)P=0.001］，29%［模型 2:HR=0.71，95%CI:(0.57，0.88)，P=0.002］和 24%［模型 3:HR=0.76，95%CI:(0.60，0.96)， 析表明 CDAI与卒中呈剂量-反应负相关，而与全因死亡呈倒 “U”相关(非线性均 P<0.001)。亚组分析表明 CDAI与卒中的负相关效应受性别和高血压影响(交互作用 P=0.006和 0.024)。结论 CDAI与卒中呈剂量 -反应式负相关，而与卒中病人的全因死亡率呈倒 “U”式相关，增P=0.023］。RCS分， |
| 英文摘要: |
| Objective To investigate the associations of composite dietary antioxidant index (CDAI) with stroke and all-cause mortali-ty in stroke.Methods We included the data of 43 210 adults from the National Health and Nutrition Examination Survey (NHANES) spanning 2001―2018 in the analysis. CDAI was calculated based on dietary intakes of vitamins A, C, E, carotenoids, as well as zincand selenium, and the participants were assigned into low group, moderate group, and high group according to the tertile space. Multi-ple logistic regression analyses were used to analyze the association between CDAI and stroke, while Cox proportional risk models wereused to analyze the association between CDAI and all-cause mortality in stroke patients. Restricted cubic spline (RCS) was used to as-sess the nonlinear relationships of CDAI in relation to stroke and all-cause mortality. And subgroup analysis was used to assess the sta-bility for the correlation effects. Results Logistic regression analyses showed that the OR of the high group in Model 1 was 0.52 [95%CI:(0.46,0.58), P<0.001], the OR in Model 2 was 0.74 [95%CI:(0.65, 0.85), P<0.001], and the OR in Model 3 was 0.79 [95%CI: (0.68,0.92),P=0.002]. Cox risk models showed that compared with the low group, the risk of all-cause death in the high group was re-duced by 28% [Model 1:HR=0.72,95%CI:(0.99, 0.88), P=0.001] and ,29%[Model 2:HR=0.71,95%CI:(0.57, 0.88), P=0.002] and ,24% [Model 3:HR=0.76,95%CI:(0.60, 0.96), P=0.023]. RCS analysis showed that CDAI was negatively associated with stroke in a dose-re-sponse pattern, whereas it was associated with the risk of all-cause death in an inverse "U" shape (all P<0.001 for nonlinearity). Sub-group analysis showed that the negative association between CDAI and stroke was influenced by gender and hypertension (P=0.006 and 0.024 for interactions). Conclusion CDAI was negatively associated with stroke in a dose-response pattern, while presented an in-versely "U"-shaped association with all-cause mortality in stroke patients, increasing dietary antioxidant nutrients may reduce the risk of stroke and all-cause death in stroke. |
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