| 徐然,吴亚男,王建美.血清 C1q/肿瘤坏死因子相关蛋白、趋化素样因子 -1对子痫前期的诊断效能[J].安徽医药,2025,29(5):987-990. |
| 血清 C1q/肿瘤坏死因子相关蛋白、趋化素样因子 -1对子痫前期的诊断效能 |
| Serum levels of CTRP6 and CKLF1 in patients with preeclampsia and their diagnostic efficacy |
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| DOI：10.3969/j.issn.1009-6469.2025.05.026 |
| 中文关键词: 先兆子痫 C1q/肿瘤坏死因子相关蛋白 趋化素样因子 -1 孕妇 妊娠期 |
| 英文关键词: Pre-eclampsia C1q/tumor necrosis factor related protein Chemokine-like factor-1 Pregnant women Gestational period |
| 基金项目:廊坊市科技支撑计划项目( 2022013125) |
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| 中文摘要: |
| 目的探讨子痫前期(PE)病人血清 C1q/肿瘤坏死因子相关蛋白( CTRP6)、趋化素样因子 -1(CKLF1)的表达水平及其对 PE的诊断效能。方法选取 2021年 12月至 2022年 10月河北中石油中心医院确诊并收治的 PE孕妇为研究对象，根据病情严重程度，将 PE病人分为轻度 PE组( 35例)和重度 PE组( 35例)另选取同期收治的正常妊娠期孕妇 35例作为对照组。酶联免疫吸附分析( ELISA)检测所有研究对象血清 CTRP6、CKLF1表达，水平； Pearson相关性分析 PE孕妇血清 CTRP6与 CKLF1之间的相关性；通过受试者操作特征曲线( ROC曲线)探讨 CTRP6、CKLF1及联合检测对 PE发生的诊断价值； logistic回归分析重度 PE发生的影响因素。结果对照组、轻度 PE组、重度 PE组孕妇收缩压［( 101.71±12.23)mmHg、(143.39±16.23)mmHg、(186.88±21.34)mmHg］、舒张压［( 67.29±9.37)mmHg、(94.16±8.91)mmHg、(116.22±11.34)mmHg］、 24 h尿蛋白水平［( 0.19±0.04)g、(1.20±0.23)g、(2.35±0.41)g］及血清 CKLF1水平［( 29.63±4.17)ng/L、(31.65±3.61)ng/L、(34.77±6.75)ng/L］依次升高( P<0.05)，血清 CTRP6水平［(645.29±61.40)μg/L、(612.63±33.98)μg/L、(510.23±39.79)μg/L］依次降低( P<0.05)； Pearson相关性分析表明， PE病人血清 CTRP6与 CKLF1呈负相关( r=.0.45，P<0.001)；血清 CTRP6、CKLF1诊断 PE的曲线下面积( AUC)分别为 0.74，0.68，其灵敏度分别为 62.9%，64.3%，特异度分别为 37.2%，68.5%；两者联合诊断 PE的 AUC为 0.87，其灵敏度、特异度分别为 71.4%、68.5%；多因素 logistic回归分析表明， CTRP6、CKLF1是影响重度 PE发生的危险因素( P<0.05)。结论 PE病人血清 CTRP6水平显著降低， CKLF1水平显著升高，且两者联合检测对 PE的发生具有较高的诊断效能。 |
| 英文摘要: |
| Objective To investigate the expression levels of C1q/tumor necrosis factor-related protein (CTRP6) and chemokine-like factor-1 (CKLF1) in serum of patients with preeclampsia (PE) and their diagnostic efficacy for PE.Methods The PE pregnant womenwho were diagnosed and treated in Hebei Petro China Central Hospital from December 2021 to October 2022 were regarded as thestudy subjects, according to the severity of the disease, PE patients were grouped into mild PE group (35 cases) and severe PE group(35 cases), in addition, 35 normal pregnant women were regarded as the control group. The the expression levels of CTRP6 and CKLF1in serum of all subjects were detected by enzyme-linked immunosorbent assay (ELISA); Pearson correlation was applied to analyze thecorrelation between CTRP6 and CKLF1 in the serum of PE pregnant women; receiver operating characteristic curve (ROC) was appliedto explore the diagnostic value of CTRP6, CKLF1 and combined detection for PE; logistic regression was applied to analyze the influ-encing factors of severe PE.Results Systolic blood pressure [(101.71±12.23) mmHg, (143.39±16.23) mmHg, (186.88±21.34) mmHg],diastolic blood pressure [(67.29±9.37) mmHg, (94.16±8.91) mmHg, (116.22±11.34) mmHg], 24-hour urine protein [(0.19±0.04) g,(1.20±0.23) g, (2.35±0.41) g] and serum CKLF1 level [(29.63±4.17) ng/L, (31.65±3.61) ng/L, (34.77±6.75) ng/L] of pregnant women incontrol group, mild PE group and severe PE group were increased successively (P<0.05), while serum CTRP6 level [(645.29±61.40) μg/ L, (612.63±33.98) μg/L, (510.23±39.79) μg/L] was decreased successively (P<0.05); Pearson correlation analysis showed that there was a negative correlation between serum CTRP6 and CKLF1 in PE patients (r=.0.45, P<0.001); the area under the curve (AUC) of se-rum CTRP6 and CKLF1 for diagnosis of PE was 0.74 and 0.68, respectively, with sensitivity of 62.9% and 64.3% respectively, specific-ity of 37.2% and 68.5% respectively; the AUC of combined diagnosis of PE was 0.87, and its sensitivity and specificity were 71.4% and68.5% respectively; multivariate logistic regression analysis showed that CTRP6 and CKLF1 were the risk factors affecting the occur-rence of severe PE (P<0.05).Conclusion Serum CTRP6 level is significantly lower and CKLF1 level is significantly higher in patients with PE, and the combined detection of both has high diagnostic efficacy for the occurrence of PE. |
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