| The digestive system is a major target Orientia tsutsugamushi (Ot) infection. Its damage is the most frequent clinical manifes-tation of scrub typhus aside from the classic "triad of high fever, eschar and rash". The digestive system comprises the esophagus, stom-ach, duodenum, liver, gallbladder, biliary tract, pancreas, small intestine, colon, and rectum, including both solid organs (e.g., liver andpancreas) and hollow organs (e.g., esophagus, stomach, and intestines). Ot infection induces inflammation, swelling and exudation in sol-id organs, while causing inflammation, ulceration, bleeding, perforation, and other critical conditions in hollow organs. Delayed etiologi-cal diagnosis and treatment may result in severe complications like multiple organ failure. Accurate diagnosis hinges on recognizing Otinfection clues, such as scrub typhus' "triad of high fever, eschar, and rash", outdoor exposure history, and reduced eosinophil count. Italso involves conducting Ot etiological tests, laboratory tests, imaging studies, and applying the "scrub typhus diagnostic scoring scale". |
