| 原栋洋,薛敏,李智,等.病理性瘢痕的治疗研究进展[J].安徽医药,2025,29(6):1065-1070. |
| 病理性瘢痕的治疗研究进展 |
| Advances in research on the treatment of pathological scarring |
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| DOI：10.3969/j.issn.1009-6469.2025.06.002 |
| 中文关键词: 瘢痕 瘢痕疙瘩 增生性瘢痕 激光治疗 治疗机制 |
| 英文关键词: Cicatrix Keloid Hyperplant scars Laser thereapy Therapeutic mechanisms |
| 基金项目:山西省科技厅重点研发项目( 201803D31141) |
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| 摘要点击次数: 84 |
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| 中文摘要: |
| 病理性瘢痕是一种良性皮肤纤维过度增生性疾病，分为增生性瘢痕和瘢痕疙瘩两种类型，这两种类型的瘢痕都与过度纤维化有关，这主要是因为成纤维细胞的异常增殖和胶原的过度沉积。病理性瘢痕的发病率、复发率高，因此疾病的治疗较为棘手；病理性瘢痕的治疗方法包括手术治疗和非手术治疗，手术切除是最直接且有效的方法，但术后复发率很高，经常联合术后放疗以达到预期效果；而非手术治疗方法包括局部注射(包括类固醇激素、 A型肉毒毒素、钙通道阻滞剂、抗肿瘤药物等)、激光治疗、放射治疗、压迫治疗、外用硅酮凝胶等。该研究拟就目前病理性瘢痕治疗方法的国内外进展进行综述，并探讨各种治疗方法联合应用的优势及应用前景。 |
| 英文摘要: |
| Pathological scarring is a benign cutaneous fibroproliferative disorder categorized into hypertrophic scars and keloids, bothassociated with excessive fibrosis primarily driven by abnormal fibroblast proliferation and collagen overdeposition. Due to its high inci-dence and recurrence rates, pathological scarring remains therapeutically challenging. Current treatments include surgical and nonsur-gical approaches. Surgical excision, though the most direct and effective method, suffers from high postoperative recurrence rates and isfrequently combined with adjuvant radiotherapy to improve outcomes. Nonsurgical modalities encompass: intralesional injections (corti-costeroids, botulinum toxin type A, calcium channel blockers, antineoplastic agents), laser therapy, radiotherapy, compression therapy,topical silicone gel. This review summarizes global advancements in pathological scar management and explores the synergistic benefitsand future prospects of combined therapeutic strategies. |
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