| 王丽,张翠,张丽娟.伐昔洛韦联合普瑞巴林配合光疗法治疗急性带状疱疹对病人疼痛及 DLQI评分的影响[J].安徽医药,2025,29(6):1147-1150. |
| 伐昔洛韦联合普瑞巴林配合光疗法治疗急性带状疱疹对病人疼痛及 DLQI评分的影响 |
| Effect of valacyclovir combined with pregabalin and phototherapy on pain and DLQI score in patients with acute herpes zoster |
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| DOI：10.3969/j.issn.1009-6469.2025.06.016 |
| 中文关键词: 带状疱疹 伐昔洛韦 普瑞巴林 光疗法 威伐光理疗 疼痛 |
| 英文关键词: Herpes zoster Valacyclovir Pregabalin Phototherapy WIRA light physiotherapy Pain |
| 基金项目:河北省中医药管理局科研计划项目( 2021221) |
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| 中文摘要: |
| 目的探讨伐昔洛韦联合普瑞巴林配合红外辐照(威伐光理疗)治疗急性带状疱疹对病人疼痛及皮肤病生活质量指数 |
| 英文摘要: |
| Objective To explore the effects of valacyclovir combined with pregabalin and WIRA (water-filtered infrared-A) light physiotherapy on pain and DLQI (dermatology life quality index) score in patients with acute herpes zoster.Methods A total of 140 pa-tients with acute herpes zoster treated at Shijiazhuang Third Hospital from September 2020 to May 2022 were were randomly divided in-to study and control groups using a random number table (70 cases each). The control group was treated with valacyclovir combinedwith pregabalin, while the study group received additional WIRA light physiotherapy for 2 weeks. Symptom improvement times (blistercessation, scab formation, and scab shedding) was compared. Pain intensity and quality of life were assessed using the Visual AnalogueScale (VAS) and DLQI before and after treatment. Serum levels of substance P (SP), β-endorphin (β-EP), interleukin-2 (IL-2), and tu-mor necrosis factor-α (TNF-α) were measured. Total clinical efficacy and postherpetic neuralgia incidence were analyzed. Results The study group showed significantly shorter times to blister cessation, scab formation, and scab shedding than the control group (all P< 0.05). Both groups had reduced VAS and DLQI scores post-treatment, but reductions were greater in the study group (P<0.05). Post-treatment serum SP, IL-2, and TNF-α levels were lower in the study group (all P<0.05), while β-EP was higher (P<0.05). The study group achieved higher clinical efficacy [95.72% (67/70) vs. 85.71% (60/70)], P<0.05] and lower postherpetic neuralgia incidence [1.43% (1/70) vs. 12.86% (9/70), P<0.05].Conclusion Valacyclovir, pregabalin, and WIRA light physiotherapy significantly improveoutcomes in acute herpes zoster by accelerating symptom resolution, reducing pain, enhancing quality of life, and lowering postherpeticneuralgia risk, with favorable safety. |
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