| 张静,鲁金乐,卫迎朝.疏肝益气养营汤联合左旋甲状腺素钠片治疗肝郁痰凝证甲状腺癌术后病人的临床疗效[J].安徽医药,2025,29(6):1265-1269. |
| 疏肝益气养营汤联合左旋甲状腺素钠片治疗肝郁痰凝证甲状腺癌术后病人的临床疗效 |
| Clinical efficacy of Shugan Yiqi Yangying decoction combined with levothyroxine sodium tablets in the postoperative treatment of thyroid cancer patients with liver stagnation and phlegm coagulation syndrome |
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| DOI：10.3969/j.issn.1009-6469.2025.06.042 |
| 中文关键词: 甲状腺肿瘤 手术后医护 疏肝益气养营汤 左旋甲状腺素钠片 肝郁痰凝证 甲状腺切除术 中医证候评分 |
| 英文关键词: Thyroid neoplasms Postoperative care Shugan Yiqi Yangying decoction Levothyroxine sodium tablets Liver stag-nation and phlegm coagulation syndrome Thyroidectomy Traditional Chinese medicine syndrome score |
| 基金项目:河北省中医药类科学研究课题计划项目( 2023244) |
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| 中文摘要: |
| 目的探究疏肝益气养营汤联合左旋甲状腺素钠片治疗肝郁痰凝证甲状腺癌术后病人的临床疗效。方法采用随机数字表法将 2022年 2月至 2023年 2月于石家庄市第三医院和河北省沧州中西医结合医院治疗的肝郁痰凝证甲状腺癌术后病人 110例分为观察组( 55例)和对照组( 55例)。对照组进行左旋甲状腺素钠片治疗，观察组在对照组的基础上给予疏肝益气养营汤治疗。对两组中医证候评分、临床疗效、甲状腺素水平、促甲状腺激素(TSH)相关抗体和不良反应进行比较。结果治疗后，两组的各项中医证候积分显著降低，且观察组下降的水平高于对照组( P<0.05)；观察组的临床总有效率［ 90.91%(50/55)］显著高于对照组［70.91%(39/55)］(P<0.05)；两组的游离三碘甲状腺原氨酸(FT3)游离甲状腺素(FT4)水平显著升高， TSH、促甲状腺激素受体抗体(TRAb)甲状腺过氧化物酶抗体(TPOAb)水平显著降低，且观察、组 FT3和 FT4上升的幅度和 TSH、TRAb、TPOAb下降的幅度都高于对照组(、P<0.05)；两组病人血清肿瘤特异性生长因子(TSGF)、血管内皮生长因子(VEGF)水平显著下降，且观察组中 TSGF、VEGF下降的幅度显著高于对照组(P<0.05)；观察组的不良反应率低于对照组(P<0.05)。结论疏肝益气养营汤联合左旋甲状腺素钠片治疗肝郁痰凝证甲状腺癌术后病人的效果较好，可改善中医证候评分和甲状腺激素水平，且安全性较高。 |
| 英文摘要: |
| Objective To explore the clinical efficacy of Shugan Yiqi Yangying decoction combined with levothyroxine sodium tab-lets in the treatment of postoperative thyroid cancer patients with liver stagnation and phlegm coagulation syndrome.Methods A ran-dom number table was used to assign 110 postoperative patients with thyroid cancer combined with liver stagnation and phlegm coagu-lation syndrome, who were treated at Shijiazhuang Third Hospital and Cangzhou Hospital of Integrated TCM-WM·Hebei from February 2022 to February 2023, into an observation group (n=55) and a control group (n=55). The control group was treated with levothyroxine sodium tablets, while the observation group was treated with Shugan Yiqi Yangying decoction in addition to levothyroxine sodium tab-lets. The TCM syndrome scores, clinical efficacy, thyroid hormone levels, thyroid stimulating hormone (TSH) related antibodies, and ad-verse reactions were compared between the two groups.Results After treatment, the TCM syndrome scores of both groups decreasedsignificantly, with a more obvious reduction in the observation group (P<0.05). The total clinical effective rate of the observation group was significantly higher than that of the control group [90.91% (50/55) vs. 70.91% (39/55)] (P<0.05). The levels of free triiodothyronine (FT3) and free tetraiodothyronine (FT4) were significantly increased in both groups, while the levels of TSH, thyroid stimulating receptorantibody (TRAb), and thyroid peroxidase antibody (TPOAb) were significantly decreased. Moreover, the observation group showed ahigher increase in FT3 and FT4 levels and a greater decrease in TSH, TRAb, and TPOAb levels compared to the control group (P<0.05).The serum levels of tumor specific growth factor (TSGF) and vascular endothelial growth factor (VEGF) significantly decreased in bothgroups, with a more obvious TSGF and VEGF decrease in the observation group (P<0.05). The adverse reaction rate in the observation |
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