| 陈锴庆,汤欣雨,王琰,等.趋化因子在再生障碍性贫血诊治中的研究进展[J].安徽医药,2025,29(7):1273-1277. |
| 趋化因子在再生障碍性贫血诊治中的研究进展 |
| Research progress on the role of chemokines in the treatment of aplastic anemia |
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| DOI：10.3969/j.issn.1009-6469.2025.07.001 |
| 中文关键词: 贫血，再生障碍性 趋化因子类 骨髓造血微环境 发病机制 诊断治疗 |
| 英文关键词: Anemia,aplastic Chemotactic factors Bone marrow hematopoietic microenvironment Pathogenesis Diagnosis and treatment |
| 基金项目:国家自然科学基金项目( 82174181)；山东省自然科学基金重点项目( ZR2020KH023)；山东省自然科学基金联合项目( ZR2022LZY014)；泰山学者青年专家项目( tsqn202211351) |
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| 摘要点击次数: 1065 |
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| 中文摘要: |
| 再生障碍性贫血(aplastic anemia，AA)是一组由多种病因所致的骨髓造血功能衰竭性综合征，以骨髓造血细胞增生减低和外周血全血细胞减少为特征，临床以贫血、出血和感染为主要表现。其发病机制目前尚不明确。近年来，骨髓造血微环境失衡及其中各类因子的表达在 AA中的作用机制成为重点研究方向。其中，趋化因子家族是骨髓造血微环境中的重要部分，能够参与免疫细胞分化、调节免疫细胞聚集、进而影响造血功能，与 AA的发病关联密切，因而，趋化因子可能是影响 AA发生发展的重要因素。该研究通过系统性阐述、分析探讨各类趋化因子在 AA中的作用及其机制，发现趋化因子及其受体在 AA的诊断、预后评估和治疗中的潜在应用，以及趋化因子在 AA中可能的参与机制，以期为 AA的临床研究提供参考。 |
| 英文摘要: |
| Aplastic anemia (AA) is a syndrome of bone marrow hematopoietic failure caused by various etiologies, characterized by re-duced hematopoietic cell proliferation in the bone marrow and decreased total blood cells in the peripheral blood, with anemia, bleed-ing, and infection as the main clinical manifestations. The pathogenesis of AA is currently unclear. In recent years, the imbalance of thebone marrow hematopoietic microenvironment and the mechanism of various factor expressions in AA have become the foci of research.Among them, the chemokine family is an important part of the bone marrow hematopoietic microenvironment, participating in immunecell differentiation, regulating the aggregation of immune cells, and thus affecting hematopoietic function, which is closely related to theonset of AA. Therefore, chemokines may play an important role in affecting the occurrence and development of AA. This study system-atically elaborates and analyzes the roles and mechanisms of various chemokines in AA, explores the potential applications of chemo-kines and their receptors in the diagnosis, prognostic evaluation, and treatment of AA as well as their possible underlying mechanismsin the disease, and thus providing references for clinical research on AA. |
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