| 国伟,伊忻.白藜芦醇在心肌缺血再灌注损伤中的作用研究进展[J].安徽医药,2025,29(7):1290-1294. |
| 白藜芦醇在心肌缺血再灌注损伤中的作用研究进展 |
| Research progress in roles of resveratrol in myocardial ischemia-reperfusion injury |
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| DOI：10.3969/j.issn.1009-6469.2025.07.005 |
| 中文关键词: 藜芦属 心肌缺血再灌注损伤 氧化应激 炎症 凋亡 自噬 钙超载 铁死亡 |
| 英文关键词: Veratrum Myocardial ischemia reperfusion injury Oxidative stress Inflammation Apoptosis Autophagy Cal-cium overload Ferroptosis |
| 基金项目:山东省老年医学会科技发展计划项目( LKJGG2021W064) |
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| 中文摘要: |
| 心肌缺血再灌注损伤是指缺血心肌恢复血流灌注后，心肌组织反而出现损伤进行性加重的现象。研究显示，导致心肌缺血再灌注损伤的机制可能与炎症反应、氧化应激、细胞凋亡、自噬、钙超载、铁死亡等有关。白藜芦醇是从植物中提取的天然多酚类化合物，具有抗氧化应激、抗炎、抗细胞凋亡、抗肿瘤、抗衰老等多种药理学活性，具有治疗诸多疾病的潜力和靶点。该文就近年来关于白藜芦醇在心肌缺血再灌注损伤中的作用及相关机制的研究进行综述，为进一步探索白藜芦醇的药用价值提供思路。 |
| 英文摘要: |
| Myocardial ischemia-reperfusion injury refers to the progressive aggravation of myocardial injury after the restoration ofblood flow perfusion in ischemic myocardium. Research has shown that the pathophysiological mechanisms leading to myocardial isch-emia-reperfusion injury may be related to inflammatory response, oxidative stress, cell apoptosis, autophagy, calcium overload, and fer-roptosis. Resveratrol is a natural polyphenolic compound extracted from plants with various pharmacological activities such as antioxi-dant stress resistance, anti-inflammation, anti-apoptosis, anti-tumor and anti-aging, which has the potential and target for the treatmentof many diseases. This article reviews the role of resveratrol in myocardial ischemia reperfusion injury and its related mechanisms in re-cent years, and provides ideas for further exploration of the medicinal value of resveratrol. |
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