| 范志巍,张海鹂,李金枝,等.SIRI与 TG/HDL-C评估急性高脂血症性胰腺炎严重程度的价值研究[J].安徽医药,2025,29(7):1324-1328. |
| SIRI与 TG/HDL-C评估急性高脂血症性胰腺炎严重程度的价值研究 |
| Assessment value of SIRI and TG/ HDL-C in evaluating the severity of hyperlipidemic acute pancreatitis |
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| DOI：10.3969/j.issn.1009-6469.2025.07.012 |
| 中文关键词: 急性高甘油三酯血症胰腺炎 全身炎症反应指数 甘油三酯 高密度脂蛋白胆固醇 Ranson评分 病情严重程度 |
| 英文关键词: Acute hypertriglyceridemic pancreatitis Systemic inflammatory response index Triglycerides High-density lipopro-tein cholesterol Ranson score Disease severity |
| 基金项目:徐州市卫生健康委医学科技创新项目( XWKYHT20220079) |
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| 中文摘要: |
| 目的探讨全身炎症反应指数( SIRI)、甘油三酯与高密度脂蛋白胆固醇比值( TG/HDL-C)评估急性高脂血症性胰腺炎(HLAP)严重程度的价值，早期识别具有重症风险的病人。方法收集 2022年 1月至 2024年 2月收入徐州仁慈医院治疗的 HLAP病人 100例作为研究对象。根据修订版亚特兰大分类标准，分为轻症组( MAP组) 57例和非轻症组( non-MAP组) 43例。计算出 SIRI值、 TG/HDL-C值及 Ranson评分。应用受试者操作特征曲线( ROC曲线)分析 3项指标对重症病人的诊断价值。结SIRI水平相互比较， non-MAP组 8.82(7.00，11.81)高于 MAP组 4.91(3.29，7.38)(P<0.05)TG/HDL-C水平相互比较， non-MAP组果12.08(12.08，16.00)高于 MAP组 8.11(6.46，11.79)(P<0.05)。 ROC曲线显示 Ranson评分、S，IRI、TG/HDL-C评估 HLAP严重度的 AUC及其 95%CI分别是 0.70(0.59，0.80)、 0.76(0.66，0.86)、 0.72(0.62，0.82)，SIRI的灵敏度( 81.40%)及特异度( 71.93%)均高于 TG/HDL-C及 Ranson评分。 3项指标联合预测 non-MAP的 AUC及其 95%CI、灵敏度、特异度为 0.88(0.82，0.94)、 83.72%、 80.70%，联合指标的 AUC值、灵敏度及特异度均最高。结论 SIRI及 TG/HDL-C可以作为早期评估 HLAP病情严重程度的指标，与 Ranson评分联用可以帮助识别重症病人。 |
| 英文摘要: |
| Objective To investigate the value of systemic inflammatory response index (SIRI) and triglyceride/high-density lipopro-tein cholesterol (TG/HDL-C) in estimating the severity of hyperlipidemic acute pancreatitis (HLAP), and to identify patients at risk ofsevere illness at an early stage.Methods A total of 100 patients with HLAP admitted to Xuzhou Renci Hospital from January 2022 toFebruary 2024 were collected as the research objects. On the basis of the revised Atlanta classification criteria, patients were dividedinto two groups, a mild disease group (MAP group) with 57 cases and a non mild disease group (non-MAP group) with 43 cases. The SIRI value, TG/HDL-C value and Ranson score were calculated. The receiver operating characteristic curve (ROC curve) was used toanalyze the diagnostic value of three indicators for critically ill patients.Results The SIRI level of non-MAP group was 8.82 (7.00, 11.81), which was higher than that of MAP group 4.91 (3.29, 7.38) (P < 0.05); the TG / HDL-C level of non-MAP group was 12.08 (12.08, 16.00), which was higher than that of MAP group 8.11 (6.46, 11.79) (P < 0.05). The ROC curve showed that the AUCs of Ran‐son score, SIRI, TG/HDL-C for assessing HLAP severity were 0.70 (0.59, 0.80), 0.76 (0.66, 0.86), and 0.72 (0.62, 0.82), respectively.The sensitivity (81.40%) and specificity (71.93%) of SIRI were higher than TG/HDL-C and Ranson score. The combined use of the three indicators as predictive indicators for non-MAP yielded an AUC of 0.88 (0.82, 0.94), with a sensitivity of 83.72% and a specificityof 80.70%.The AUC area, sensitivity and specificity of the combined index were the highest.Conclusion SIRI and TG/HDL-C can be used as reference indicators for early assessment of the severity of HLAP. Combination of the two indicators and Ranson score can helpidentify critically ill patients. |
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