| 屈小莹,夏曼,陈浩,等.Bickerstaff脑干脑炎 13例临床研究[J].安徽医药,2025,29(7):1386-1390. |
| Bickerstaff脑干脑炎 13例临床研究 |
| Clinical study of 13 cases of Bickerstaff's brainstem encephalitis |
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| DOI：10.3969/j.issn.1009-6469.2025.07.024 |
| 中文关键词: 脱髓鞘自身免疫疾病，中枢神经 Bickerstaff脑干脑炎 Miller-Fisher综合征 临床特点 抗 GQ1b抗体 磁共振成像 |
| 英文关键词: Demyelinating autoimmune diseases,central nervous system Bickerstaff's brainstem encephalitis Miller-Fisher syn-drome Clinical features Anti-GQ1b antibodies Magnetic resonance imaging |
| 基金项目:江苏省高校省级重点实验室开放课题项目( XZSYSKF2020010) |
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| 中文摘要: |
| 目的探讨 Bickerstaff脑干脑炎(BBE)的临床特征、诊断依据、治疗方法以及预后情况。方法通过回顾性分析 2018年 10月至 2023年 9月 13例于徐州医科大学附属医院确诊的脑干脑炎病人的临床资料，总结 BBE病人的临床特点和预后情况。结果研究对象均为急性或亚急性起病。 8例有前驱感染病史。首发症状中，眼部症状占 7例、头晕占 3例、共济失调占 2例、识不清占 1例。 6例脑脊液检查显示白蛋白细胞分离， 9例抗 GQ1b抗体阳性。头颅磁共振( MRI)显示 6例颅内有异常信号灶。意脑电图检查 3例轻度异常。肌电图检查 1例存在脱髓鞘改变。结论 BBE的诊断主要依据临床表现，抗 GQ1b抗体检测、脑脊液检查、影像学和神经电生理可作为辅助诊断。治疗上使用免疫球蛋白或激素治疗有效。 BBE疾病病程多呈单相性，预后良好。 |
| 英文摘要: |
| Objective To explore the clinical features, diagnostic criteria, treatment methods, and prognosis of Bickerstaff's brain-stem encephalitis (BBE).Methods Retrospective analysis of clinical data of 13 patients diagnosed with brainstem encephalitis at Affil-iated Hospital of Xuzhou Medical University from October 2018 to September 2023, and the clinical characteristics and prognostic out-comes of BBE patients were summarized.Results All subjects had an acute or subacute onset. Eight patients had a history of preced-ing infections. Among the initial symptoms, ocular symptoms were present in 7 cases, dizziness in 3 cases, ataxia in 2 cases, and alteredconsciousness in 1 case. Cerebrospinal fluid examination showed albuminocytological dissociation in 6 patients, and 9 patients werepositive for anti-GQ1b antibodies. Head magnetic resonance imaging (MRI) showed abnormal signal lesions in the brain in 6 patients.Electroencephalogram examination showed mild abnormalities in 3 patients. Electromyogram examination showed demyelination chang-es in 1 patient.Conclusions The diagnosis of BBE is mainly based on clinical manifestations, anti-GQ1b antibody detection, cerebro-spinal fluid examination, imaging, and neurophysiology as auxiliary diagnostic methods. Treatment with immunoglobulins or steroids iseffective. BBE is usually monophasic with a good prognosis. |
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