| 田秦秦,王海波.“转化化学”视域下科教融合型有机化学综合实验设计:吩噻嗪类荧光探针的合成及次氯酸检测应用[J].安徽医药,2025,29(7):1471-1478. |
| “转化化学”视域下科教融合型有机化学综合实验设计:吩噻嗪类荧光探针的合成及次氯酸检测应用 |
| Experimental design of science and education integrated organic chemistry from the perspective of "Translational Chemistry": synthesis of phenothiazine fluorescent probes and application of hypochlorous acid detection |
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| DOI：10.3969/j.issn.1009-6469.2025.07.042 |
| 中文关键词: 教学实验 转化化学 教学方法 有机化学 科教融合 荧光探针 吩噻嗪类 次氯酸 |
| 英文关键词: Teaching experiment Translational chemistry Teaching method Organic chemistry Science and education inte-gration Fluorescent probes Phenothiazine Hypochlorous acid |
| 基金项目:国家自然科学基金项目( 81973236)；陕西省重点研发计划一般项目( 2024SF-YBXM-094)；中华医学会医学教育研究课题项目( 2023B146) |
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| 中文摘要: |
| 在化学、生物学、医学交叉融合的“转化化学”背景下，探索与生物医学、临床实践相关的学科前沿，创新成果融入医学本科实验教学，丰富现有实验教学内容，对于培养交叉学科复合创新型医学专业人才至关重要。科教融合策略下，设计集有机合成、结构表征、数据解析、机理验证于一体的“吩噻嗪类荧光探针的合成及次氯酸检测应用”有机化学综合实验。通过该实验的学习，有利于拓展学生对交叉学科前沿发展的视野，从临床应用问题出发，充分调动学生的学习热情，实验内容丰富，综合性强，系统化培育学生的批判性思维与创新性思维，同步构建起遵循实证研究规范的科学认知框架与恪守实验伦理的科研行为准则。 |
| 英文摘要: |
| Under the background of "Translational Chemistry", which integrates chemistry, biology and medicine, it is of great impor-tance to explore the frontier of disciplines related to biomedicine and clinical practice, integrate innovative achievements into the exper-imental teaching of medical undergraduates, and enrich the existing experimental teaching content for cultivating interdisciplinary com-pound and innovative medical professionals. A comprehensive organic chemistry experiment of "Synthesis of phenothiazine fluorescentprobes and application of hypochlorous acid detection" was designed by integrating organic synthesis, structural characterization, dataanalysis and mechanism verification through the strategy of science and education integration. Through the study of this experiment, itis beneficial to broaden students' horizons on the cutting-edge development of interdisciplinary fields. Starting from clinical applicationproblems, it fully mobilizes students' learning enthusiasm. The experimental content is rich, comprehensive, and systematically culti-vates students' critical thinking and innovative thinking. At the same time, it constructs a scientific cognitive framework that followsempirical research norms and a scientific research behavior code that adheres to experimental ethics. |
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