| 郭文秀,牟华明.动脉粥样硬化抗炎治疗的研究进展与展望[J].安徽医药,2025,29(8):1490-1495. |
| 动脉粥样硬化抗炎治疗的研究进展与展望 |
| Research progress and prospect of anti-inflammatory therapy for atherosclerosis |
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| DOI：10.3969/j.issn.1009-6469.2025.08.002 |
| 中文关键词: 动脉粥样硬化 抗炎药 炎症反应 冠心病 C反应蛋白 NOD样受体蛋白 3(NLRP3) |
| 英文关键词: Atherosclerosis Anti-inflammatory drug Inflammatory reaction Coronary disease C-reactive protein NOD-like receptor protein 3 (NLRP3) |
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| 摘要点击次数: 1032 |
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| 中文摘要: |
| 血脂异常和炎症共同促进动脉粥样硬化性心血管疾病( ASCVD)发生发展，接受降脂、抗血小板标准二级预防治疗的 ASCVD病人心血管不良事件发生率仍较高，心血管残余炎症风险可能在其中占主导地位。近年来，动脉粥样硬化抗炎治疗受到广泛关注和研究，抗炎治疗初显成效。该研究总结了近年来有关靶向抗炎治疗、广泛抗炎治疗、中药抗炎治疗和靶向训练免疫等的相关研究，以期为该领域提供新的治疗策略和靶点。 |
| 英文摘要: |
| Dyslipidemia and inflammation jointly promote the development of atherosclerotic cardiovascular disease (ASCVD), andthe incidence of adverse cardiovascular events in ASCVD patients receiving lipid-lowering, antiplatelet standardized secondary preven-tion therapy remains high, in which the risk of residual cardiovascular inflammation may predominate. In recent years, anti-inflamma-tory therapy for atherosclerosis has received extensive attention and research, and anti-inflammatory therapy has shown initial success. This article summarizes relevant studies on targeted anti-inflammatory therapy, broad-based anti-inflammatory therapy, herbal anti-in-flammatory therapy, and target-training immunity in recent years, with a view to providing new therapeutic strategies and targets in this field. |
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