| 熊璐,郭莲.沉默信息调节因子家族与非酒精性脂肪肝的研究进展[J].安徽医药,2025,29(8):1502-1508. |
| 沉默信息调节因子家族与非酒精性脂肪肝的研究进展 |
| Research progress on sirtuins and non-alcoholic fatty liver disease |
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| DOI：10.3969/j.issn.1009-6469.2025.08.004 |
| 中文关键词: 非酒精性脂肪性肝病 沉默信息调节因子 氧化应激 胰岛素抵抗 研究进展 |
| 英文关键词: Non-alcoholic fatty liver disease Sirtuins Oxidative stress Insulin resistance Research progress |
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| 中文摘要: |
| 非酒精性脂肪肝( NAFLD)是目前世界上最常见的慢性肝病之一，也逐渐成为了肝移植的首要病因，发病年龄也逐渐年轻化，但其发病机制尚不明确，且无具体的治疗措施，所以寻找一个可靠有效的生化标志物，对于疾病的早诊断、早治疗、早预防显得刻不容缓。近期研究中，沉默信息调节因子( SIRT)家族在 NAFLD的作用逐渐被发现，主要参与 NAFLD的糖脂代谢、氧化应激、内质网应激、线粒体生物合成等过程，现对 SIRT家族在 NAFLD中的作用机制等方面进行综述。 |
| 英文摘要: |
| Non-alcoholic fatty liver disease (NAFLD) is currently one of the most prevalent chronic liver diseases worldwide and hasprogressively become the leading cause of liver transplantation, with an increasingly younger age of onset. However, its pathogenesis re-mains unclear, and there are no specific treatment measures available. Therefore, identifying reliable and effective biochemical markersfor early diagnosis, treatment, and prevention of the disease is urgently needed. Recent studies have gradually revealed the role of thesirtuin (SIRT) family in NAFLD, primarily involving processes such as glucose and lipid metabolism, oxidative stress, endoplasmic re-ticulum stress, and mitochondrial biogenesis in NAFLD. This article reviews the mechanisms of action of the SIRT family in NAFLD. |
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