| 高洁,原大江,王孝茹.肠道菌群失调与急性呼吸窘迫综合征中的“肠-肺轴”：从机制到干预[J].安徽医药,待发表. |
| 肠道菌群失调与急性呼吸窘迫综合征中的“肠-肺轴”：从机制到干预 |
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| 投稿时间：2025-08-12 录用日期：2025-09-25 |
| DOI： |
| 中文关键词: ARDS 肠-肺轴 肠道菌群 代谢产物 微生态干预 |
| 英文关键词: |
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| 中文摘要: |
| 急性呼吸窘迫综合征（ARDS）是一种急性炎症性肺损伤，病死率高且缺乏特异性治疗手段。研究表明，肠道菌群及其代谢产物可通过“肠-肺轴”参与ARDS的发生发展。患者常表现为菌群多样性下降、共生菌减少、条件致病菌增加及短链脂肪酸、次级胆汁酸、吲哚类等代谢产物水平下降，导致肠屏障受损、炎症反应加剧和肺部免疫失衡。益生菌、益生元、粪菌移植及饮食干预等微生态策略可改善菌群结构、增强屏障功能并减轻肺部炎症，但其在ARDS中的疗效与安全性仍需进一步验证。本文着重于综述肠道菌群的具体代谢产物在ARDS中的最新机制研究，将有助于拓展ARDS治疗的新方向，并可能为精准化治疗提供新的思路。 |
| 英文摘要: |
| Acute respiratory distress syndrome (ARDS) is an acute inflammatory lung injury characterized by high mortality rates and a lack of specific treatments. Research indicates that gut microbiota and their metabolic products participate in the development of ARDS through the “gut-lung axis.” Patients often exhibit reduced microbiota diversity, decreased commensal bacteria, increased opportunistic pathogens, and decreased levels of metabolic products such as short-chain fatty acids, secondary bile acids, and indoles, leading to impaired intestinal barrier function, exacerbated inflammatory responses, and pulmonary immune imbalance. Microecological strategies such as probiotics, prebiotics, fecal microbiota transplantation, and dietary interventions can improve microbiota structure, enhance barrier function, and reduce pulmonary inflammation. However, their efficacy and safety in ARDS require further validation. This paper focuses on reviewing the latest mechanistic studies of specific gut microbiota metabolites in ARDS, which will help to explore new directions for ARDS treatment and may provide new insights for precision medicine. |
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