| 张莹,权丽,樊宽鲁.炎症指标与非酒精性脂肪性肝病纤维化程度的相关性研究[J].安徽医药,2025,29(8):1573-1577. |
| 炎症指标与非酒精性脂肪性肝病纤维化程度的相关性研究 |
| Study on the correlation between inflammatory markers and fibrosis degree in nonalcoholic fatty liver disease |
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| DOI：10.3969/j.issn.1009-6469.2025.08.017 |
| 中文关键词: 非酒精性脂肪性肝纤维化 炎症指标 中性粒细胞与淋巴细胞比值 全身炎症反应指数 |
| 英文关键词: Non-alcoholic fatty liver disease-related fibrosis Inflammatory markers Neutrophil-to-lymphocyte ratio Systemic inflammatory response index |
| 基金项目:徐州医科大学附属医院发展基金( XYFC2020005) |
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| 中文摘要: |
| 目的探索炎症指标与非酒精性脂肪性肝病( NAFLD)纤维化的相关性。方法收集 2022年 9月至 2023年 3月在徐州医科大学第二附属医院进行体检的年龄范围为 18~80岁人群体检数据，根据诊断标准，分为非脂肪肝组和脂肪肝组并进行一般资料对比，再根据纤维化 -4(FIB-4)评分分级标准，将脂肪肝人群分为脂肪肝非纤维化组( F0)、脂肪肝可疑纤维化组( F1)和脂肪肝纤维化组( F2)，采用多元 logistic回归分析不同程度的脂肪肝纤维化的危险因素。结果 NAFLD病人占总人数的 43.2%(3 152/7 292)，与非脂肪肝组相比，脂肪肝组男性、超重及肥胖人群占比、年龄等偏高。脂肪肝人群中 F2组占比为 2.0%， F2组中女性患病率较男性偏高。与 F0相比， F2组年龄、丙氨酸转氨酶( ALT)、天冬氨酸转氨酶( AST)、总胆红素、直接胆红素(DBil)、空腹血糖、高密度脂蛋白胆固醇( HDL-C)、中性粒细胞与淋巴细胞比值( NLR)［1.88(1.46，2.26)比 1.58(1.26，1.98)］、全身炎症反应指数( SIRI)［0.71(0.52，1.12)比 0.70(0.50，0.98)］等指标水平均升高。多因素 logistic回归分析结果显示，在排除混杂因素后， NAFLD肝纤维化程度随着 NLR(OR=2.20)、 SIRI(OR=6.10)水平升高而上升。结论高 NLR和高 SIRI水平属于 NAFLD肝纤维化发展的独立危险因素，可作为辅助诊断和防控指标。 |
| 英文摘要: |
| Objective To explore the correlation between inflammatory markers and fibrosis in nonalcoholic fatty liver disease (NAFLD).Methods We collected physical examination data from individuals aged 18-80 years who underwent check-ups at the Sec-ond Affiliated Hospital of Xuzhou Medical University between September 2022 and March 2023. Participants were divided into a non-fatty liver group and a fatty liver group based on diagnostic criteria for baseline comparison. The fatty liver population was further strati-fied into non-fibrosis (F0), suspected fibrosis (F1), and fibrosis (F2) groups according to the FIB-4 scoring system. Multivariate logistic regression was used to analyze risk factors for varying degrees of fatty liver.Results NAFLD patients accounted for 43.2% (3 152/7 292) of the total cohort. Compared to the non-fatty liver group, the fatty liver group had a higher proportion of males, overweight/obeseindividuals, and older participants. Within the fatty liver group, the F2 subgroup comprised 2.0% of cases, with a higher prevalenceamong females than males. Relative to F0, the F2 group showed elevated levels of age, alanine transaminase (ALT), aspartate transami-nase (AST), total bilirubin, direct bilirubin (DBil), fasting blood glucose, high-density lipoprotein cholesterol (HDL-C), neutrophil-to-lymphocyte ratio (NLR) [1.88 (1.46, 2.26) vs. 1.58 (1.26, 1.98)], and systemic inflammation response index (SIRI) [0.71 (0.52, 1.12) vs. 0.70 (0.50, 0.98)]. Multivariate logistic regression confirmed that NAFLD fibrosis severity increased with higher NLR (OR = 2.20) and SIRI (OR = 6.10) after adjusting for confounders.Conclusion Elevated NLR and SIRI levels are independent risk factors for NAFLD-related liver fibrosis progression and may serve as auxiliary diagnostic and preventive indicators. |
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