| 唐泉青,陈李豪,黄高振,等.盆腔孤立性纤维性肿瘤 3例临床分析并文献复习[J].安徽医药,2025,29(8):1592-1596. |
| 盆腔孤立性纤维性肿瘤 3例临床分析并文献复习 |
| Clinical analysis of three cases of solitary fibrous tumors of the pelvis and review of the literature |
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| DOI：10.3969/j.issn.1009-6469.2025.08.021 |
| 中文关键词: 盆腔肿瘤 孤立性纤维性肿瘤 波形蛋白 白细胞分化抗原 34 B淋巴细胞瘤 -2 信号转导与转录激活因子 6 预后 |
| 英文关键词: Pelvic neoplasms Solitary fibrous tumors Vimentin Cluster differentiation 34 B-cell lymphoma-2 Signal trans-duction and activator of transcription 6 Prognosis |
| 基金项目:广东省基础与应用基础研究基金项目( 2022A1515012195；2024A1515012742) |
| 作者 | 单位 | E-mail | | 唐泉青 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 陈李豪 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 黄高振 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 李世豪 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 许志坚 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 叶木石 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 李建昌 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | | | 刘宏伟 | 广东医科大学附属医院, 泌尿外科,泌尿外科研究室,广东湛江,524001 | lhwhongwei@gdmu.edu.cn |
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| 中文摘要: |
| 目的探讨盆腔孤立性纤维性肿瘤的临床病理学特征、诊断与鉴别诊断、治疗及预后。方法对广东医科大学附属医院 2019年 12月至 2022年 10月收治的 3例盆腔孤立性纤维性肿瘤病人的临床、病理学资料进行分析，并复习相关文献。结果 3例病人中，男性 2例，女性 1例，年龄范围为 44~52岁。 3例病人术后病理均为盆腔孤立性纤维性肿瘤，肿瘤细胞呈短梭形或卵圆形，呈杂乱、席纹或血管外皮瘤样排列，细胞异型性不明显，核分裂象少见。免疫组织化学染色显示 3例波形蛋白( Vi-mentin)、白细胞分化抗原 34(CD34)、 B淋巴细胞瘤 -2(Bcl-2)基因、白细胞分化抗原 99(CD99)、信号转导与转录激活因子 6(STAT6)均阳性，结蛋白( Desmin)均阴性。随访 11~44个月， 3例均无肿瘤复发或转移。结论盆腔孤立性纤维性肿瘤是一种少见的肿瘤，其临床症状、体征及影像学检查均无特殊性，临床确诊主要依靠病理形态学和免疫表型。手术切除是主要治疗方法，大部分病人预后良好，但需要长期随访。 |
| 英文摘要: |
| Objective To explore the clinicopathological characteristics, diagnosis, differential diagnosis, treatment, and prognosis ofpelvic solitary fibrous tumors.Methods We analyzed the clinical and pathological data of three patients with pelvic solitary fibrous tu-mors admitted to the Affiliated Hospital of Guangdong Medical University from December 2019 to October 2022 and reviewed relevantliteratures.Results Among the three patients, two were male and one was female, aged between 44 and 52 years. Postoperative patho-logical examination confirmed pelvic solitary fibrous tumors in all cases. The tumor cells were short spindle-shaped or oval, arranged indisordered, patchy or vascular patterns, with no significant cell atypia and rare mitotic figures. Immunohistochemical staining showedpositivity for vimentin, CD34, Bcl-2, CD99, and STAT6 in all three cases, while desmin was negative. Follow-up for 11 to 44 months re-vealed no tumor recurrence or metastasis in any patient.Conclusions Pelvic solitary fibrous tumors are rare, with nonspecific clinicalsymptoms, signs, and imaging findings. Accurate diagnosis relies on pathological morphology and immunophenotype. Surgical resectionis the primary treatment, and most patients have a favorable prognosis but require long-term follow-up. |
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