| 程喜旺.通窍活血汤联合多奈哌齐对轻中度阿尔茨海默病患者认知功能及血清8-OHdG、Nrf2水平的影响[J].安徽医药,待发表. |
| 通窍活血汤联合多奈哌齐对轻中度阿尔茨海默病患者认知功能及血清8-OHdG、Nrf2水平的影响 |
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| 投稿时间：2025-08-26 录用日期：2025-09-26 |
| DOI： |
| 中文关键词: 通窍活血汤 多奈哌齐 阿尔茨海默 认知功能 8-羟基脱氧鸟苷、核因子E2相关因子2 |
| 英文关键词: |
| 基金项目:河北省中医院管理局资助项目 编号:2025606 |
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| 中文摘要: |
| 目的:探讨通窍活血汤联合多奈哌齐对轻中度阿尔茨海默病(AD)患者认知功能及血清8-羟基脱氧鸟苷(8-OHdG)、核因子E2相关因子2(Nrf2)水平的影响。方法:选取邯郸市中西医结合医院在2024年7月至2025年6月收治的106例轻中度AD患者,采用随机数字表法分为两组。常规组口服盐酸多奈哌齐片治疗,联合组在常规组基础加用通窍活血汤治疗。比较两组治疗前后的认知功能、日常生活能力以及痴呆程度,并检测血清8-OHdG、Nrf2水平,观察不良反应发生情况。结果:两组患者治疗后,蒙特利尔认知评估量表(MoCA)评分、阿尔茨海默病协作研究日常生活能力量表(ADCS-ADL)评分以及血清Nrf2水平显著升高(P＜0.05),且联合组升高幅度优于常规组(P＜0.05)；而中医证候积分、阿尔茨海默病评估量表-认知分量表(ADAS-cog)评分、临床痴呆评定量表(CDR)评分以及血清8-OHdG水平在治疗后显著降低(P＜0.05),且联合组低于常规组(P＜0.05)。联合组与常规组不良反应发生率比对[15.09%(8/53)vs 11.32%(6/53)]差异不显著(P＞0.05)。结论:通窍活血汤联合多奈哌齐用于轻中度AD患者,可改善其认知功能,同时降低血清8-OHdG水平,提升Nrf2水平。 |
| 英文摘要: |
| Objective: To discuss the effects of combination of Tongqiao Huoxue Tang and donepezil on cognitive function and serum 8-hydroxydeoxyguanosine (8-OHdG) and nuclear factor E2 related factor 2 (Nrf2) in patients with mild to moderate Alzheimer"s disease (AD). Methods: From July 2024 to June 2025, 106 patients with mild to moderate AD in our hospital were included and randomly assigned into two groups via random number table. The regular group adopted oral administration of donepezil hydrochloride tablets, while the combination group adopted Tongqiao Huoxue Tang on the top of the regular group. The pre- and post-medication cognitive function, daily living ability, and degree of dementia were compared, the serum 8-OHdG and Nrf2 were detected, and bad reactions were observed. Results: After medication, the Montreal Cognitive Assessment Scale (MoCA) score, Alzheimer"s Disease Cooperative Study-Activities of Daily Living Inventory (ADCS-ADL) score, and serum Nrf2 conspicuously increased in both groups (P<0.05), and the increase in the combination group was better than that in the regular group (P<0.05); the scores of Chinese medicine syndrome, Alzheimer"s Disease Assessment Scale-Cognitive Subscale (ADAS cog), Clinical Dementia Rating (CDR), and serum 8-OHdG were conspicuously reduced after medication (P<0.05), and with the combination group being lower than the regular group (P<0.05). There was no conspicuous difference in bad reactions between the combination group and the regular group [15.09% (8/53) vs. 11.32% (6/53)] (P>0.05). Conclusion: The combination of Tongqiao Huoxue Tang and donepezil can improve cognitive function in patients with mild to moderate AD, and reduce serum 8-OHdG and increase Nrf2. |
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