| 李争光,林朝晖,汪莉萍.ALBI和 EZ-ALBI对肝细胞癌术后辅助性经导管动脉化疗栓塞术预后的价值[J].安徽医药,2025,29(8):1626-1629. |
| ALBI和 EZ-ALBI对肝细胞癌术后辅助性经导管动脉化疗栓塞术预后的价值 |
| The value of ALBI and EZ-ALBI in the prognosis of adjuvant TACE after curative hepatectomy for HCC |
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| DOI：10.3969/j.issn.1009-6469.2025.08.028 |
| 中文关键词: 癌，肝细胞 经导管动脉化疗栓塞术 放化疗，辅助 白蛋白 -胆红素评分 简易 -白蛋白 -胆红素评分 预后 |
| 英文关键词: Carcinoma, hepatocellular Transcatheter arterial chemoembolization Chemoradiotherapy, adjuvant Albumin-biliru-bin score Easy albumin-bilirubin score Prognosis |
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| 中文摘要: |
| 目的研究白蛋白 -胆红素( ALBI)评分和简易 -白蛋白 -胆红素( EZ-ALBI)评分对肝癌根治术后病人辅助性经导管动脉化疗栓塞术( TACE)预后的价值。方法回顾性分析 2017年 1月至 2020年 12月徐州医科大学附属医院收治的肝细胞癌根治术后辅助性 TACE病人 112例。根据病人术前白蛋白和胆红素计算 ABLI评分和 EZ-ALBI评分，分析两种评分对肝细胞癌根治术后辅助性肝动脉化疗栓塞预后的价值。结果 ALBI评分和 EZ-ALBI评分的曲线下面积(AUC)分别为 0.65和 0.68，最佳截断值为 .2.64分和 .37.01分。 ALBI<.2.64分组中位生存时间为 45个月， ALBI≥.2.64分组中位生存时间为 35个月，组间差异有统计学意义( P<0.001)； EZ-ALBI<.37.01分组中位生存时间为 45个月， EZ-ALBI≥.37.01分组中位生存时间为 34个月，差异有统计学意义( P<0.001)。单因素 Cox分析结果显示术前丙氨酸转氨酶( ALT)≥32 U/L、γ-谷氨酰转移酶( GGT)≥62 U/L、肿瘤长径 ≥ 5 cm、白蛋白( ALB)<42.1 g/L、ALBI≥.2.64分、 EZ-ALBI≥.37.01分是肝细胞癌根治术后辅助性 TACE病人总生存期降低的危险因素( P<0.05)。多因素 Cox分析结果显示，术前 EZ-ALBI≥.37.01分是肝细胞癌根治术后辅助性 TACE病人总生存期降低的独立危险因素(P<0.05)。结论术前 EZ-ALBI评分可作为肝细胞癌根治术后辅助性 TACE病人预后的参考性指标。 |
| 英文摘要: |
| Objective To explore the value of the albumin-bilirubin (ALBI) score and the easy albumin-bilirubin (EZ-ALBI) score inthe prognosis of adjuvant transcatheter arterial chemoembolization (TACE) in patients following curative hepatectomy for hepatocellularcarcinoma (HCC). Methods A retrospective analysis was performed on 112 patients admitted to the Affiliated Hospital of XuzhouMedical University for adjuvant TACE after curative hepatectomy between January 2017 and December 2020. The ABLI and EZ-ALBI scores were calculated, based on preoperative albumin and bilirubin levels, and their prognostic value was analyzed was analyzed.Re. sults The AUCs for the ALBI and EZ-ALBI scores were 0.65 and 0.68, with optimal cutoff values of .2.64 points and .37.01 points.The median survival was 45 months in the ALBI < .2.64 points group versus 35 months in the ALBI ≥ .2.64 points group (P < 0.001), and 45 months in the EZ-ALBI < .37.01 points group versus 34 months in the EZ-ALBI ≥ .37.01 points group (P < 0.001). Univariate Cox regression identified preoperative alanine aminotransferase (ALT) ≥ 32 U/L, γ-glutamyl transferase (GGT) ≥ 62 U/L, tumor diame-ter ≥ 5 cm, albumin (ALB) < 42.1 g/L, ALBI ≥ .2.64 points and EZ-ALBI ≥ .37.01 points as risk factors for reduced survival (P < 0.05). Multivariate Cox regression showed that preoperative EZ-ALBI ≥ .37.01 points was an independent risk factor for decreased sur-vival. Multivariate Cox regression showed that preoperative EZ-ALBI ≥ .37.01 points was an independent risk factor for decreased sur-vival (P < 0.05).Conclusion The preoperative EZ-ALBI score can serve as a useful prognostic indicator for HCC patients undergoing adjuvant TACE after curative hepatectomy. |
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