| 罗娅娟,曹烨民,董海生.NLR、APTT对软组织感染的脓毒症病人合并急性肾损伤早期预测价值[J].安徽医药,2025,29(8):1634-1638. |
| NLR、APTT对软组织感染的脓毒症病人合并急性肾损伤早期预测价值 |
| Early predictive value of NLR and APTT in septic patients with soft tissue infections and acute kidney injury |
| |
| DOI：10.3969/j.issn.1009-6469.2025.08.030 |
| 中文关键词: 脓毒症 软组织感染 急性肾损伤 中性粒细胞与淋巴细胞比值 活化部分凝血活酶时间 预测作用 |
| 英文关键词: Sepsis Soft tissue infection Acute kidney injury Neutrophil-to-lymphocyte ratio Activated partial thromboplastin time Predictive role |
| 基金项目:上海市虹口区第二轮“国医强优”三年行动计划项目( HKGYQYXM-2022-07) |
|
| 摘要点击次数: 543 |
| 全文下载次数: 237 |
| 中文摘要: |
| 目的探讨中性粒细胞与淋巴细胞比值( NLR)及活化部分凝血活酶时间( APTT)对软组织感染的脓毒症病人合并急性肾损伤( AKI)的早期预测价值。方法回顾性分析 2019年 1月至 2022年 12月上海市中西医结合医院重症监护室诊治的软组织感染的脓毒症病人临床资料，根据是否发生 AKI将病人分为 AKI组及非 AKI组，比较两组间的临床资料，采用 logistic回归模型分析软组织感染的脓毒症病人合并 AKI的独立危险因素，并通过受试者操作特征曲线(ROC曲线)评估这些独立危险因素对软组织感染的脓毒症病人合并 AKI早期预测价值。结果共纳入 70例软组织感染的脓毒症病人中， AKI组 38例，非 AKI组 32例。 AKI组的乳酸、白细胞、 NLR［40.24(30.44，45.08)比 33.69(23.74，40.81)］、 APTT［45.0(42.0，46.0)s比 40.2(40.0，46.0)s］、肌酐、尿素氮、凝血酶原时间、 D-二聚体、序贯器官衰竭评估( SOFA)评分均高于非 AKI组(均 P<0.05)其余指标均差异无统计学意义( P>0.05)。 logistic回归结果显示， NLR升高、 APTT延长是软组织感染的脓毒症病人合并 AKI的独，立危险因素；经过 ROC曲线分析 NLR预测软组织感染的脓毒症合并 AKI的曲线下面积( AUC)为 0.67［95%CI:(0.54，0.80)P=0.011］APTT的 AUC为 0.66［95%CI:(0.51，0.80)P=0.031］，NLR联合 APTT的 AUC为 0.76［95%CI:(0.64，0.87)，P<0.001］LR的阈值为 23.74，N，诊断，APTT的诊断阈值为 40.2 s，N，LR联合 APTT的灵敏度为 89.79%，特异度为 78.12%。结论 NLR升高联，合 APTT延长可以作为软组织感染的脓毒症病人合并 AKI早期预测指标。 |
| 英文摘要: |
| Objective To explore the early predictive value of the neutrophil-to-lymphocyte ratio (NLR) and activated partial throm-boplastin time (APTT) for acute kidney injury (AKI) in septic patients with soft tissue infections.Method This retrospective study ana-lyzed clinical data from septic patients with soft tissue infections treated in the intensive care unit of Shanghai Hospital of IntegrativeMedicine between January 2019 and December 2022. Patients were divided into AKI and non-AKI groups. Logistic regression identi-fied independent risk factors for AKI, and receiver operating characteristic (ROC) curves assessed the predictive value of these factors.Results The study included 70 patients (38 in the AKI group, 32 in the non-AKI group). The AKI group had significantly higher lac-tate, white blood cell count, NLR [40.24 (30.44, 45.08) vs. 33.69 (23.74, 40.81)], APTT [45.0 (42.0, 46.0) s vs. 40.2 (40.0, 46.0) s], cre-atinine, urea nitrogen, prothrombin time, D-dimer, and SOFA scores (all P< 0.05). Logistic regression identified elevated NLR and pro-longed APTT as independent risk factors for AKI. The AUC for NLR in predicting AKI was 0.67 [95%CI: (0.54, 0.80), P= 0.011], for APTT it was 0.66 [95%CI: (0.51, 0.80), P= 0.031], and for NLR combined with APTT, it was 0.76 [95%CI: (0.64, 0.87), P< 0.001]. Thediagnostic thresholds were 23.74 for NLR and 40.2 s for APTT, with a combined sensitivity of 89.79% and specificity of 78.12%.Con. clusion Elevated NLR combined with prolonged APTT can serve as an early predictive indicator for AKI in septic patients with softtissue infections. |
|
查看全文
查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
