| 苗丽晓,杨超,马建彩,等.血清 FGF2，LMR，sPs在早发型子痫前期病人中的表达及其早期诊断价值[J].安徽医药,2025,29(8):1651-1655. |
| 血清 FGF2，LMR，sPs在早发型子痫前期病人中的表达及其早期诊断价值 |
| Expression and early diagnostic value of serum FGF2, LMR, sPs in patients with early-onset preeclampsia |
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| DOI：10.3969/j.issn.1009-6469.2025.08.034 |
| 中文关键词: 先兆子痫 成纤维细胞生长因子 2 单核细胞数和淋巴细胞数的比值 溶性 P选择素 早期诊断 |
| 英文关键词: Preeclampsia Fibroblast growth factor 2 Lymphocyte-to-monocyte ratio Soluble P-selectin Early diagnosis |
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| 中文摘要: |
| 目的探究早发型子痫前期( EOPE)病人血清成纤维细胞生长因子 2(FGF2)单核细胞数和淋巴细胞数的比值( LMR)，溶性 P选择素( sPs)表达水平及其对 EOPE的早期诊断价值。方法随机抽签选取202，2年 8月至 2023年 7月在邯郸市中心医院就诊的 112例 EOPE病人作为研究对象( EOPE组)，随机抽签选取同期在该院进行孕期检查健康的 115例孕妇作为对照组，收集两组年龄、身体质量指数( BMI)、糖尿病家族史、凝血四项、 D-二聚体水平、 C反应蛋白水平等一般临床资料，比较两组血清 FGF2，LMR，sPs表达；采用多因素 logistic回归分析影响孕期发生 EOPE的因素；采用受试者操作特征曲线( ROC曲线)分析血清 FGF2，LMR，sPs水平对 EOPE的早期诊断效能。结果 EOPE组和对照组的年龄、孕前 BMI、糖尿病家族史、吸烟、饮酒、 PE家族史、孕期增重以及产次均差异无统计学意义( P>0.05)两组收缩压、舒张压、凝血酶原时间、活化部分凝血酶原时间、凝血酶时间、纤维蛋白原水平、 D-二聚体水平、 C反应蛋白水平、，新生儿质量均差异有统计学意义( P<0.05)； EOPE组血清 FGF2［( 11.35±3.02)ng/L比( 8.33±2.79)ng/L］，LMR(4.41±1.27比 3.32±0.83)，sPs［(110.37±15.32)ng/L比( 94.65±12.15)ng/L］表达水平均显著高于对照组(t=7.83、7.67、8.58，P<0.05)；多因素 logistic回归结果显示 FGF2、LMR、sPs、D-二聚体、 C反应蛋白水平均是孕期发生 EOPE的危险因素( P<0.05)； ROC曲线显示 FGF2、LMR、sPs水平和三者联合诊断 EOPE的曲线下面积( AUC)及其 95%CI分别为 0.79(0.73，0.84)、 0.76(0.70，0.81)，0.79(0.73，0.84)、 0.92(0.88，0.96)三者联合应用早期诊断 EOPE的临床效能优于血清 FGF2，LMR，sPs单独预测( Z三者联合 -FGF2=4.98、Z三者联合 -LMR=5.13、Z三者联合 -sPs=5.1，1，均 P<0.001)。结论 EOPE病人血清 |
| 英文摘要: |
| Objective To investigate the expression levels of serum fibroblast growth factor 2 (FGF2), lymphocyte-to-monocyte ratio (LMR), and soluble P-selectin (sPs) in early-onset preeclampsia (EOPE) patients and their early diagnostic value.Methods This studyincluded 112 EOPE patients (EOPE group) and 115 healthy pregnant women (control group) who underwent prenatal examinations atHandan Central Hospital from August 2022 to July 2023. General clinical data such as age, body mass index (BMI), diabetes family his-tory, coagulation parameters, D-dimer, C-reactive protein (CPR) levels were collected. Serum FGF2, LMR, and sPs levels were com-pared between groups. Multivariate logistic regression identified EOPE risk factors, and receiver operating characteristic curves (ROC)evaluated biomarker diagnostic performance.Results No significant differences were observed between groups in age, pre-pregnancyBMI, diabetes family history, smoking, alcohol consumption, preeclampsia family history, pregnancy weight gain, or parity (P>0.05).Significant differences existed in systolic/diastolic blood pressure, prothrombin time, activated partial prothrombin time, prothrombintime, fibrinogenl, D-dimer, CRP levels, and neonatal weight (P < 0.05). The EOPE group exhibited higher serum FGF2 [(11.35 ± 3.02) ng/L vs. (8.33 ± 2.79) ng/L], LMR (4.41±1.27 vs. 3.32 ± 0.83), and sPs [(110.37 ± 15.32) ng/L vs. (94.65 ± 12.15) ng/L] compared to controls (t=7.83, 7.67, 8.58; P < 0.05); Multivariate analysis identified FGF2, LMR, sPs, D-dimer, and CRP as EOPE risk factors (P< 0.05). The ROC curve showed that the levels of FGF2, LMR, sPs, and the area under the curve (AUC) and their 95% confidence inter-vals for the combined diagnosis of EOPE were 0.79 (0.73, 0.84), 0.76 (0.70, 0.81), 0.79 (0.73, 0.84), and 0.92 (0.88, 0.96), respectively,the combined application of the three methods for early diagnosis of EOPE had better clinical efficacy than serum FGF2, LMR and sPs alone (Zcombined-FGF2= 4.98, Zcombined-LMR= 5.13, Zcombined-sPs= 5.11, all P <0.001).Conclusion Serum FGF2, LMR, and sPs levels are elevatedin EOPE patients, and their combination demonstrates high clinical value for early EOPE diagnosis. |
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