| 李智洁,陈璐,焦晴晴,等.儿童线状 IgA大疱性皮病 1例并文献复习[J].安徽医药,2025,29(8):1674-1676. |
| 儿童线状 IgA大疱性皮病 1例并文献复习 |
| One case report of Linear IgA bullous dermatosis of childhood and literature review |
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| DOI：10.3969/j.issn.1009-6469.2025.08.039 |
| 中文关键词: 线状 IgA大疱性皮肤病 免疫荧光技术 儿童 水疱 糖皮质激素 文献复习 |
| 英文关键词: Linear IgA bullous dermatosis Immunofluorescent technique Child Blister Glucocorticoid Literature review |
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| 中文摘要: |
| 目的增加临床医生对线状 IgA大疱性皮病( LABD)的认识。方法 2017年 5月至 2019年 5月对 1例儿童 LABD的临床资料、组织病理、直接免疫荧光检测及治疗经过进行回顾，并查阅相关文献进行综合分析 LABD的病因、发病机制、临床表现、诊断、鉴别诊断及治疗。结果病儿临床表现多发性粟粒至黄豆大小厚壁水疱，基部皮肤正常或为红斑，结合组织病理和直接免疫荧光确诊为儿童 LABD。予口服泼尼松片，疗程约 2年，皮疹无反复。结论 LABD是一种慢性获得性表皮下大疱病，病因不明，发病机制不确切，诊断主要依靠直接免疫荧光检测发现基底膜带上 IgA线状沉积。糖皮质激素治疗可取得良好效果。 |
| 英文摘要: |
| Objective To improve clinicians' understanding of linear IgA bullous dermatosis (LABD). Methods The clinical data,histopathology, direct immunofluorescence detection and treatment of a children with LABD from May 2017 to May 2019 were re-viewed, and the relevant literature was reviewed, and the relevant literature was reviewed to comprehensively analyze the etiology,pathogenesis, clinical manifestations, diagnosis, differential diagnosis and treatment of LABD.Results The clinical manifestations of the child were multiple miliary to soybean size thick-wall blisters with normal or erythema at the base of the skin. Combined with histo-pathology and direct immunofluorescence, the child was diagnosed as LABD.Administer oral prednisone tablets for about 2 years, withno recurrence of rash.Conclusions LABD is a chronic acquired subepidermal bullous disease with unknown etiology and uncertainpathogenesis. The diagnosis mainly depends on direct immunofluorescence detection of linear IgA deposition in the basement mem-brane. Glucocorticoid therapy can also achieve good results. |
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