| 陆明敏,白明明,乔丽.血清卵泡抑素样蛋白 1、半乳糖凝集素 -3水平与寻常型银屑病病人疾病严重程度的相关性[J].安徽医药,2025,29(8):1677-1681. |
| 血清卵泡抑素样蛋白 1、半乳糖凝集素 -3水平与寻常型银屑病病人疾病严重程度的相关性 |
| Correlation between serum FSTL1, Gal-3 levels and disease severity in patients with psoriasis vulgaris |
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| DOI：10.3969/j.issn.1009-6469.2025.08.040 |
| 中文关键词: 寻常型银屑病 病人病情 卵泡抑素样蛋白 1 半乳糖凝集素 -3 相关性 |
| 英文关键词: Psoriasis vulgaris Patient acuity Follistatin-like protein 1 Galectin-3 Correlation |
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| 中文摘要: |
| 目的探究卵泡抑素样蛋白 1(FSTL1)、半乳糖凝集素 -3(Gal-3)在寻常型银屑病( PsV)病人血清中的表达以及其与病人疾病严重程度之间的相关性。方法前瞻性选取 2021年 2月至 2023年 1月中国人民解放军空军特色医学中心收治的 90例 PsV病人为疾病组，另选取同时期该院接收的 90例体检健康者为健康组。采用酶联免疫吸附分析( ELISA)法测定受试者血清 FSTL1、Gal-3水平；采用银屑病皮损面积和严重程度指数( PASI)量表评估疾病组病人疾病严重程度。采用 Pearson相关性分析 PsV病人血清 FSTL1、Gal-3水平与 PASI评分的相关性。另根据临床特征与疾病进展情况，将 PsV病人分为退行期、静止期、进行期，并分析不同疾病分期的 PsV病人 FSTL1、Gal-3以及 PASI评分差异。结果疾病组血清 FSTL1［(8.80±2.00)μg/L比( 4.79±0.75)μg/L］、 Gal-3［( 11.25±2.61)μg/L比( 5.14±0.87)μg/L］水平高于健康组( P<0.05)。 Pearson分析表示， PsV病人血清 FSTL1、 Gal-3水平均与 PASI评分正相关(r=0.72，P<0.001；r=0.53，P<0.001)。退行期、静止期、进行期 PsV病人血清 FSTL1［(6.26±1.90) μg/L、(8.09±1.96)μg/L、(11.65±2.11)μg/L］、 Gal-3水平［( 9.62±2.41)μg/L、(11.22±2.65)μg/L、(12.77±2.76)μg/L］、 PASI评分［( 7.55±3.03)分、(12.80±2.75)分、(20.82±2.67)分］依次升高( F=61.20、11.78、182.69，均 P<0.001)。结论 PsV病人血清 FSTL1、Gal-3水平均升高，二者均与 PsV病人疾病严重程度呈正相关。 |
| 英文摘要: |
| Objective To investigate the expression of follistatin like protein 1 (FSTL1) and galectin-3 (Gal-3) in the serum of pa-tients with psoriasis vulgaris (PsV) and their correlation with disease severity.Methods From February 2021 to January 2023, 90 pa-tients with PsV admitted to the Chinese People's Liberation Army Air Force Characteristic Medical Center were prospectively selectedas the disease group, and 90 healthy examinees from the same period were chosen as the health group. Serum levels of FSTL1 and Gal-3 were measured using enzyme-linked immunosorbent assay (ELISA). Disease severity in the disease group was assessed with the Psori-asis Lesion Area and Severity Index (PASI) scale. Pearson correlation analysis was conducted to evaluate the relationship between se-rum FSTL1, Gal-3 levels and PASI scores in PsV patients. In addition, PsV patients were categorized into regression, quiescent and pro-gressive stages based on clinical and progression characteristics, and differences in FSTL1, Gal-3 levels, and PASI scores across these stages were analyzed.Results Serum FSTL1 [(8.80±2.00) μg/L vs. (4.79±0.75) μg/L] and Gal-3 [(11.25±2.61) μg/L vs. 5.14±0.87) μg/ L] levels in the disease group were higher than those in the health group (P < 0.05). Pearson analysis revealed positive correlations be-tween serum FSTL1 and Gal-3 levels and PASI scores in PsV patients (r =0.72, P <0.001; r = 0.53, P < 0.001). Serum FSTL1 [(6.26± 1.90) μg/L, (8.09±1.96) μg/L, (11.65±2.11) μg/L], Gal-3 [(9.62±2.41) μg/L, (11.22±2.65) μg/L, (12.77±2.76) μg/L], and PASI scores[(7.55±3.03) points, (12.80±2.75) points, (20.82±2.67) points] progressively increased across the regressive, quiescent, and progressivestages (F=61.20, 11.78, 182.69, all P<0.001).Conclusion Serum FSTL1 and Gal-3 levels are elevated in PsV patients and positively correlated with disease severity. |
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