| 李凤,李月,胡涛.血管内皮锌指转录因子 1在急性脑梗死血清中的表达及与病情程度的相关性[J].安徽医药,2025,29(9):1810-1814. |
| 血管内皮锌指转录因子 1在急性脑梗死血清中的表达及与病情程度的相关性 |
| Expression of serum VEZF1 in patients with acute cerebral infarction and its correlation with the severity of the disease |
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| DOI：10.3969/j.issn.1009-6469.2025.09.023 |
| 中文关键词: 脑梗死 血管内皮锌指转录因子 1 颈动脉狭窄程度 梗死灶面积 |
| 英文关键词: Brain infarction Vascular endothelial zinc finger 1 Degree of carotid artery stenosis Infarction area |
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| 中文摘要: |
| 目的探讨血管内皮锌指转录因子 1(VEZF1)在急性脑梗死( ACI)病人血清中的表达及与病情程度的相关性。方法回顾性选取 2020年 7月至 2022年 7月遂宁市中心医院治疗的 109例 ACI病人，根据美国国立卫生研究院卒中量表评分(NIHSS)将 ACI病人分为重度组(NIHSS>14分， 27例)、中度组( 5分≤NIHSS≤14分， 47例)轻度组( NIHSS<5分， 35例)。另取同期来遂宁市中心医院进行体检的 50例健康体检者为对照组。比较血清 VEZF1、同型半胱、氨酸( Hcy)、超敏 C反应蛋白( hs-CRP)水平；分析 ACI病人血清 VEZF1水平与颈动脉狭窄程度、梗死灶面积、改良 Rankin评分量表( mRS)评分、神经功能缺损程度( NDS)评分的关系； Spearman法进行相关性分析；受试者操作特征曲线( ROC曲线)分析血清 VEZF1对鉴别重度和中 /轻度 ACI病人的临床价值。结果重度组、中度组、轻度组血清 VEZF1水平显著低于对照组［( 95.36±25.64)μg/L、(130.34±34.21) μg/L、(163.71±40.71)μg/L比( 286.27±71.33)μg/L，P<0.05］，且随着病情严重程度增加，血清 VEZF1水平有下降趋势( P<0.05)。重度组、中度组、轻度组血清 Hcy［( 20.13±5.11)μmol/L、(15.34±3.96)μmol/L、(12.22±3.10)μmol/L比( 4.87±1.32)μmol/L］、 hs-CRP水平［( 7.34±1.92)mg/L、(5.77±1.31)mg/L、(4.32±1.22)mg/L比( 2.33±0.46)mg/L］均显著高于对照组( P<0.05)，且随着病情严重程度增加，血清 Hcy、hs-CRP水平有升高趋势( P<0.05)；随着 ACI病人颈动脉狭窄程度、梗死灶面积、 mRS评分、 NDS评分增加，血清 VEZF1水平显著下降( P<0.05)；血清 VEZF1与颈动脉狭窄程度、梗死灶面积、 mRS评分、 NDS评分、 NIHSS评分均呈负相关( P<0.05)；血清 VEZF1水平鉴别重度和中 /轻度 ACI病人的曲线下面积( AUC)为 0.84，95%CI:(0.76，0.90)。结论 |
| 英文摘要: |
| Objective To investigate the expression of vascular endothelial zinc finger 1 (VEZF1) in the serum of patients with acutecerebral infarction (ACI) and its correlation with the severity of the condition.Methods A total of 109 ACI patients treated in SuiningCentral Hospitall from July 2020 to July 2022 were retrospectively selected, according to the National Institutes of Health Stroke Scale(NIHSS), ACI patients were grouped into severe group (NIHSS>14 points, 27 cases), moderate group (5 points ≤ NIHSS ≤ 14 points, 47cases), and mild group (NIHSS<5 points, 35 cases). Another 50 healthy individuals who came to Suining Central Hospital for physicalexamination during the same period were collected as the control group. The levels of serum VEZF1, homocysteine (Hcy), and high-sen-sitivity C-reactive protein (hs-CRP) were compared; the relationship between serum VEZF1 level and the degree of carotid artery steno-sis, infarct area, mRS score, and NDS score in ACI patients was analyzed; Spearman method was applied for correlation analysis; receiv-er operating characteristic (ROC) curve was applied to analyze the clinical value of serum VEZF1 in distinguishing between severe andmoderate/mild ACI patients.Results The serum VEZF1 level in the severe, moderate, and mild groups was obviously lower than thatin the control group [(95.36±25.64) μg/L, (130.34±34.21) μg/L, (163.71±40.71) μg/L vs. (286.27±71.33) μg/L, P<0.05], and as the se-verity of the disease increased, the serum VEZF1 level showed a downward trend (P<0.05). The serum Hcy [(20.13±5.11) μmol/L, (15.34±3.96) μmol/L, (12.22±3.10) μmol/L vs. (4.87±1.32) μmol/L] and hs-CRP levels [(7.34±1.92) mg/L, (5.77±1.31) mg/L, (4.32± 1.22) mg/L vs. (2.33±0.46) mg/L] in the severe, moderate, and mild groups were obviously higher than those in the control group (P< 0.05), and as the severity of the disease increased, the levels of serum Hcy and hs-CRP showed an upward trend (P<0.05); as the in-creases of degree of carotid artery stenosis, infarct area, mRS score, and NDS score in ACI patients, the serum VEZF1 level obviouslydecreased (P<0.05); serum VEZF1 was negatively correlated with the degree of carotid artery stenosis, infarct size, mRS score, NDSscore, and NIHSS score (P<0.05); the area under the curve (AUC) for distinguishing between severe and moderate/mild ACI patients with serum VEZF1 level was 0.84, 95%CI:(0.76, 0.90).Conclusion The serum VEZF1 level in ACI patients decreases and shows adecreasing trend as the severity of the condition increases, which has important clinical value in distinguishing the severity of the condi-tion in ACI patients. |
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