| 郭雯,郭建辉,赵娜,等.墨莲祛白汤联合毫火针治疗肾虚血瘀型白驳风的临床疗效观察[J].安徽医药,2025,29(9):1883-1887. |
| 墨莲祛白汤联合毫火针治疗肾虚血瘀型白驳风的临床疗效观察 |
| Clinical efficacy of Molian Qubai decoction combined with filiform needle on vitiligo of kidney deficiency and blood stasis type |
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| DOI：10.3969/j.issn.1009-6469.2025.09.039 |
| 中文关键词: 白癜风 墨莲祛白汤 毫火针 肾虚血瘀型白驳风 临床疗效 |
| 英文关键词: Vitiligo Molian Qubai decoction Filiform needle Kidney deficiency and blood stasis type vitiligo Clinical efficacy |
| 基金项目:河北省中医药管理局科研计划项目( 2022262) |
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| 中文摘要: |
| 目的观察墨莲祛白汤联合毫火针治疗肾虚血瘀型白驳风的临床疗效。方法选取 2021年 3月至 2023年 3月河北省沧州中西医结合医院收治的 80例肾虚血瘀型白驳风病人，依据随机数字表法分为观察组和对照组，对照组 40例予以常规西医治疗，观察组 40例在对照组基础上予以墨莲祛白汤联合毫火针治疗。比较两组临床疗效、皮损面积、靶皮损部位复色率、辅助性 T细胞 17/调节性 T细胞( Th17/Treg)免疫平衡状态、生活质量、安全性。结果观察组的总有效率( 92.50%比 75.00%)、靶皮损部位复色率( 95.00%比 79.49%)高于对照组( P<0.05)。治疗后，两组的皮损面积、 Th17、Th17/Treg、白细胞介素 -17(IL-17)、肿瘤坏死因子 α(TNF-α)、 γ干扰素、皮肤病生活质量指数( DLQI)评分低于治疗前( P<0.05)且观察组低于对照组( P<0.05)。治疗后，两组的 Treg高于治疗前( P<0.05)且观察组的 Treg高于对照组( P<0.05)。对照组不良，反应发生率 2.50%较观察组 10.00%差异无统计学意义(连续校正 χ2=0=0.356)。结论墨莲祛白汤联合毫火针治疗肾虚血瘀型白驳风疗效确切，能.85，P，缩小皮损面积，提高靶皮损部位复色率，恢复 Th17/Treg免疫平衡，改善生活质量，且临床使用安全。 |
| 英文摘要: |
| Objective To observe the clinical efficacy of Molian Qubai decoction combined with filiform needle on vitiligo of kidney deficiency and blood stasis type.Methods According to the random number table method, 80 patients with vitiligo of kidney deficien-cy and blood stasis type, who were admitted to Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in HebeiProvince from March 2021 to March 2023, were grouped into two groups. The control group consisted of 40 patients who received con-ventional Western medicine treatment, while the test group consisted of 40 patients who received Molian Qubai decoction combined with filiform needle treatment in addition to the conventional Western medicine treatment. A comparison was made of the clinical effica-cy, lesion area, repigmentation rate of the target lesions, Th17/Treg immune balance status, quality of life, and safety.Results The to-tal effective rate(92.50% vs. 75.00%) and repigmentation rate of the target lesions (95.00% vs. 79.49%) of the test group were higher than those of the control group (P<0.05). After treatment, the skin lesion area, Th17, Th17/Treg, interleukin-17 (IL-17), tumor necrosis factor α (TNF-α), interferon-γ, and dermatology life quality index (DLQI) scores of the two groups were lower than those before treat-ment (P<0.05), with the test group lower than the control group (P<0.05). After treatment, the Treg levels in both groups were higher than those before treatment (P<0.05), with the test group higher than the control group (P<0.05). There was no significant difference in the incidence of adverse reactions between the control group and the study group (2.50% vs. 10.00%, continuous correction χ2=0.85, P= 0.356).Conclusions The combination of Molian Qubai decoction and filiform needle has a definite therapeutic effect on vitiligo of kid-ney deficiency and blood stasis type. It can reduce the area of skin lesions, improve the repigmenation rate of target skin lesions, restoreTh17/Treg immune balance, improve quality of life, and is safe for clinical use. |
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